C−S键构建研究一直是有机化学研究的热门领域之一，越来越引起科学家们的重视。因此，发展新的合成方法实现C-S键构建，研究新型含硫功能分子及其性质研究具有重要的理论价值和现实意义。通过本项目的研究和实施，能够解决化学选择性C-S键构建反应研究中面临的几个重要科学问题：(1)推动氘代含硫试剂、硒功能化含硫试剂在有机合成中的应用研究，创新性地实现含氘代硫化物、含硒硫化物的精准合成及功能分子的氘代硫化、硒硫化改造，对相关反应及其应用进行深入研究。(2)创新性地研究廉价过渡金属催化特别是还原偶联条件下或无过渡金属存在条件下，化学选择性高效、通用策略构建硫醚特别是烷基硫醚类化合物、砜类化合物、亚砜类化合物、高价有机硫化合物等，并探索其在功能材料方面的应用。(3)促进电催化、光催化条件下含硫自由基参与的多组分反应及其调控规律研究，实现电催化、光催化条件下基于C-S成键的还原偶联反应高效构建有机硫化合物。

Organic sulfur compounds are widely found in nature and organisms. Their number in the world is only less than those containing oxygen or nitrogen heteroatoms. Various forms of sulfur compounds such as mercaptan, thioether, sulfoxide, sulfone, sulfur-containing heterocyclic compounds and polysulfide compounds exist in nature or have been successfully synthesized by scientists. Chemoselective C-S bond construction is one of the most hot research fields in organic chemistry, which has attracted more and more attention of scientists and embodied important scientific research value and application value. Therefore, it is of great theoretical value and practical significance to develop new synthetic methods to synthesis of novel sulfur-containing functional molecules through C-S bond formation and study their properties. Through the research and implementation of this project, we can solve several important scientific problems in the research of C-S bond construction chemistry..(1) We will promote the application of deuterated sulfur-containing reagents and selenium functionalized sulfur-containing reagents in organic synthesis, innovatively realize the precise synthesis of deuterated sulfides and selenium-containing sulfides as well as the modification of deuterated sulfides and selenium sulfides of functional molecules, and conduct in-depth research on related reactions and their applications...(2) We will study inexpensive transition metal catalyzed-reductive coupling or non-transition metals promoted C-S bond formation reactions to synthesis of sulfur containing compounds especially sulfides, especially alkyl sulfides, sulfones, sulfoxides and high-valent organic sulfides, and to explore their applications in functional materials...(3) We will also study of multi-component reaction as well as reductive coupling reaction reactions through to C-S bond formation to synthesis of sulfur-containing radicals under electrocatalysis and photocatalysis conditions.