腕部正中神经受到卡压而引起的神经病症，称之为腕管综合征（CTS）。CTS患者常伴有一定程度的感觉神经和运动神经功能障碍，严重者会影响手部的正常功能，更甚者可能会丧失手部的活动和操作能力。目前研究发现，正中神经受载可能与腕管内/外部载荷(直接/间接)的作用有关，但是正中神经受载导致CTS的生物力学机制还不明确。鉴于CTS的危害性，本项目采用建立详细的上肢（上臂、前臂、腕部和手指）的三维有限元分析模型的方法，探索和分析上肢（上臂、前臂、腕部和手指）不同姿势和运动时腕管内部载荷，以及键盘和鼠标操作时腕部与桌面接触等腕管外部载荷，对正中神经卡压作用的生物力学机制（包括实验测量和有限元模拟分析）。本项目对正中神经受载导致CTS的生物力学研究具有重要的学术意义，也对CTS的诊断、治疗和手术方案制定，以及术后康复评估、训练等具有重要的临床指导意义。

A neuropathy induced by the median nerve entrapment of wrist, which is called Carpal tunnel syndrome (CTS). Patients with CTS are often accompanied by a certain degree of sensory and motor nerve dysfunction, which may affect the normal function of the hand in severe cases, or even lose the hand ability to move and operate. At present, it has been found that median nerve subjected to loads may be related to the internal/external (direct/indirect) effect of carpal tunnel, but the biomechanical mechanism of CTS induced by median nerve subjected to loads is still unclear. In view of the dangers of CTS, the establishment of detailed three-dimensional finite element analysis model of upper limb (upper arm, forearm, wrist and fingers) is adopted in this project, the biomechanical mechanism of the median nerve entrapment is explored and analyzed under the actions of carpal tunnel internal load at different postures and movements of upper limbs (upper arm, forearm, wrist and fingers), and the actions of carpal tunnel external load at the keyboard and mouse operations and at the wrist contacting with desktop (including the experimental measurement and finite element simulation and analysis).This project has great academic significance to the biomechanical study of CTS caused by median nerve suffered from loads, as well as has clinical guidance meaning to the diagnosis, treatment and surgical program of CTS, and to the postoperative rehabilitation evaluation and training, etc.