本项目拟以具有重要生物活性的天然产物手性合成为导向，旨在发展高效实用的光促进催化不对称自由基多步串联新反应模式。通过底物的巧妙设计和串联反应的合理安排，我们将发展高效的、普适性广的手性催化体系，探索自由基转化的立体选择性控制的新策略，解决不对称自由基化学中化学选择性和立体选择性控制等科学问题。根据不同类型的目标天然产物生物碱的结构特征，利用合适的手性有机小分子催化剂和相应手性控制策略，开发新颖多样的催化不对称自由基串联反应类型，以精准高效的构建天然产物的核心骨架，并运用到天然产物生物碱及其同系物高效手性合成。在合成天然产物生物碱和其同系物的基础上，和生物学家合作进行药物活性测试和结构-活性关系研究。

This project is focused on the asymmetric synthesis of natural products with important biological activities, and the development of novel highly efficient and practical photocatalytic asymmetric multi-step cascade radical reactions inspired by these natural products. With ingenious design of substrates and rational arrangement of cascade reaction process, we will develop high-performance asymmetric catalytic system and explore new effective protocols for radical transformations, aiming to achieve high level of chemical selectivity and enantioselectivity in multi-step radical reactions. According to the structural characteristics of target natural product alkaloids, we will take advantage of appropriate asymmetric organo-catalysis system and corresponding enantioselective control strategy for the development a novel class of catalytic asymmetric radical cascade reactions, constructing the core structure of the natural products accurately and efficiently. Subsequent transformations will be conducted to achieve the efficient asymmetric synthesis of natural product alkaloids and their homologues. Further efforts on bioactivity testing of these products and structure-activity relationship studies will be carried out in cooperation with biologists.