儿童社区获得性肺炎多重感染的病原研究及危险因素分析

社区获得性肺炎（CAP）是儿童时期常见的感染性性疾病，而且是5岁以下儿童死亡的首要原因，难治性CAP和重症CAP发病与多重感染密切相关，但具体病原及相关危险因素尚不清楚。本项目组前期发现多重感染是儿童CAP的重要病因，且与CAP病程、严重程度及死亡率密切相关，我们推测多重感染在儿童CAP 中发挥了重要作用。鉴此，本项目组拟进一步分析多重感染的病原学特征及其临床意义；从免疫因素、气候因素、基础疾病因素、病原因素四方面分析CAP多重感染发生的高危因素及其感染形式；以及采用有效的、针对病原的抗感染治疗方案及相对应的预防措施来治疗和早期干预，为儿童CAP多重感染的防治提供科学依据。

Comunity acquired pneumonia（CAP） is a common infectious disease of childhood, and is the leading cause of death in children under five years old, intractable CAP and severe CAP is closely related to the multiple pathogen infections.The early stage of the project found that multiple infection is an important cause of children's CAP, and is closely related to the duration, severity and mortality of CAP;Therefore, we suspect that the multiple infection plays an important role in CAP.As a result, this project intends to further analyze the multiple infection of pathogens spectrum and its clinical significance in CAP; Analysis the risk factors of the CAP multiple infections From genetic factors, immune factors, environmental factors and disease, nutrition factor, and use the effective, targeted antimicrobial treatment measures and corresponding prevention measures to treat and reduce multiple infection children CAP, Provide the scientific basis for the prevention and control of strategy of multiple infection in CAP.