近年来金催化碳－碳和碳－杂键形成反应已成为现代有机合成中最强有力的工具之一。然而，昂贵的均相金盐及其配合物催化剂难以与产物分离和回收再用，其实际应用受到限制。本项目通过模拟高活性的均相Au(I)和Au(Ⅲ)配合物催化剂结构，拟设计、合成系列新型磁性纳米粒子负载氮、膦、胂、硫、氮杂环卡宾(NHC)等配体与Au(I)和Au(Ⅲ)的配合物催化剂，并对其结构进行表征。研究其在金催化的各种碳－碳键、碳－杂键形成反应及经"一锅"串联反应合成各种含氮(氧)杂环化合物中的应用。通过优化反应条件，研究金配合物结构与催化活性之间的关系，有望筛选出对某些金催化的有机反应具有高活性和优异回收再用性能的负载金配合物催化剂。高活性负载金配合物催化剂的应用将有助于大大降低反应成本和减少废弃物排放，为金催化的重要有机反应能应用于实验室大规模制备及工业应用奠定理论基础,推动有机合成化学朝着资源节约和环境保护型方向发展。

Recently, gold-catalyzed carbon-carbon bond and carbon- heteroatom bond formation reactions have become one of the most powerful tools in modern organic synthesis. However, expensive homogeneous gold salts and gold complexes catalysts cannot be recycled, and are difficult to be removed from the product, practical applications of these reactions are limited. Based on the principles of organic synthetic methodology and green chemistry, in this project we want to design and synthesize a series of novel magnetic nanoparticles(MNPs)- immobilized nitrogen, phosphine, arsine, sulfur, N-heterocyclic carbene(NHC) ligands with gold(I) or gold(III) complexes catalysts and characterize them. The novel magnetic nanoparticles (MNPs)-immobilized gold complexes will be employed as heterogeneous catalysts in a variety of gold-catalyzed carbon-carbon bond and carbon-heteroatom bond formation reactions, and in the synthesis of various kinds of nitrogen or oxygen heterocycles compounds via one-pot cascade reaction. We expect that heterogeneous gold catalysts with high activity and excellent recyclability for some gold-catalyzed organic reactions will be developed by the optimization of reaction conditions and investigation of the relationship between catalyst structures and catalytic activities. The use of highly efficient heterogeneous gold catalysts helps to reduce cost of the reaction, to minimize wastes derived from reaction workup, and to prevent product from contamination by gold. Our research work will provide a theoretical basis for the applications of gold-catalyzed important organic reactions in large-scale laboratory preparation or in industry production,and promote the development of green organic synthetic chemistry.