针对许多中药有效成分应用广泛、疗效确切，但因溶解性差、渗透性差导致的生物利用度差的现状，本项目以芹菜素、厚朴酚、川芎嗪和丹参酮II A为研究对象，设计与合成基于氢键的中药单体共晶，通过X射线衍射、红外光谱、热重分析和动态水分分析等对其理化性质进行综合评价后，制备单晶并利用Bruker SHELXTL软件包解析其结构。选择安全稳定的中药单体共晶通过体外溶出速率、体外扩散速率以及药物在Caco-2细胞模型中的摄取与转运，筛选选取合适的聚合物沉淀抑制剂(PPIs)抑制共晶药物的析晶过程，维持其超饱和状态。这为丰富中药单体晶型提供物质基础，也为中药现代化提供新思路。

Many Chinese hebal medicine have definite curative effects, but some herbal effective constituents have low bioavailability because of the low water solubility and low permeability. This project focus on designing and preparing herbal co-crystal based on hydrogen bonding to improve the bioavailability. The constituents include in this projects are apigenin, magnolia,ligustrazine and tanshinone II A. Through powder X ray diffraction (PXRD)，infrared spectroscopy (IR)，thermo gravimetric analysis (TGA) and dynamic water analysis to test the physicochemical property to design and prepare the Chinese herbal co-crystal. Analysising the co-crystal structure with Bruker SHELXTL software and selecting appropriate polymer precipitation inhibitor by the dissolution rate and diffusion rate in vitro, intake and transfer reformance in coca-2 cell, to maintain the super saturation state of the herbal co-crystal. This will enrich the crystal form of Chinese herb and provide a new way to relize modernization of Chinese medicine.