人工离子通道的设计、合成与跨膜传输研究是超分子化学的重要内容。相比于研究较为深入的人工阳离子通道，人工阴离子通道由于阴离子本身的特性诸如多几何形状、低电荷密度、易溶剂化等特点以及够借鉴的天然阴离子通道很少等因素，其发展非常缓慢。本项目基于阴离子-pi作用的原理和多重非共价弱相互作用协同的策略，针对生命体系中重要的阴离子如氯离子，硝酸根，碳酸根，硫酸根和磷酸根等，拟设计合成一系列与阴离子的几何形状和大小空间互补的、含多重阴离子-pi协同作用的大环主体分子。进而利用杂原子桥连杯杂芳烃的衍生和功能化修饰，引入不同的疏水基团，构建阴离子通道；利用囊泡技术、脂双层电导测量等技术，探索阴离子跨膜传输的动态过程。

Study of ion transport through membranes based on synthetic ion channels is an important topic in supromaolecular chemistry. In sharp contrast to the well developed synthetic cation channels, however, the anion channels remains largely unexplored most probably due to the intrinsic natures of anions, such as varied geometries, low charge density and high free energies of solvation solvation, and also few anionophores could be accessed from natural sources. This project plans to synthesize a series of macrocycle host molecules bearing multiple electron deficient aromatics, which enables the selective recognition towards the important and abundant anions in physiological solutions, such as chloride, nitrate, carbonate, sulfate and phosphate through multiple anion-pi interactions. By means of post-macrocyclization functionalization protocol, novel anion channels would be constructed. Then experimental approaches of vesicles and/or planar bilayer membranes would be carried out to study the ion transport through membranes.