三氮唑作为aza-[4C]合成子的反应研究及其在天然产物全合成中的应用

含氮杂环化合物的合成一直都是有机化学研究的热点，三氮唑在铑催化下形成的α-亚胺铑卡宾中间体含有一个氮原子，是合成含氮杂环化合物的重要中间体之一。目前研究的成环反应中，三氮唑大多作为aza-[3C]合成子参与反应，作为aza-[4C]合成子的研究极少。针对目前这一现状，本项目拟研究以三氮唑作为aza-[4C]合成子的一系列[4+n]环化反应，同时准备利用aza-[4C]合成子与[2C]合成子的[4+2]环化反应作为关键步骤，完成天然产物Communesin F的全合成。本项目研究的一系列[4+n]环化反应可以极大的丰富三氮唑作为aza-[4C]合成子的反应类型，能提供高效的合成含氮杂环化合物的新策略，同时可以利用这些反应进一步合成复杂多环化合物，为相关化合物的生物活性研究等提供帮助。

The synthesis of nitrogen-containing heterocycles has always been a hot topic in organic chemistry. The α-imine rhodium carbene formed by rhodium catalyzed denitrogenation of triazole is one of the important intermediates for the synthesis of nitrogen-containing heterocycles. In the ring formation reactions studied up to now, most triazoles participate in the reaction as aza-[3C] synthon, and in few studies as aza-[4C] synthon. In view of the current situation, this project intends to develop a series of methodologies in which triazole is used as aza-[4C] synthon. In addition, the [4+2] cyclization reaction between aza-[4C] synthon and [2C] synthon could be employed as the key step to complete the total synthesis of natural product Communesin F. A series of [4+n] cyclization reactions studied in this project could greatly enrich the reaction types of triazole as aza-[4C] synthon, and could provide new and efficient methods for the synthesis of nitrogen-containing heterocyclic compounds. In addition, these methods could be used to further synthesize complex polycyclic compounds, providing opportunity for the study of biological activities of related compounds.