BMP/Smad信号通路在维生素D与大肠癌关系中的作用研究

目前研究认为，维生素D是大肠癌的保护因素；维生素D可以激活BMP/Smad信号通路；BMP/Smad信号通路失活与大肠癌发生、发展关系密切。故推测维生素D可能通过保持BMP/Smad信号通路正常而起到降低大肠癌发病风险的作用。为验证上述研究假设，本项目拟采用病例-病例-对照研究设计，通过检测大肠癌病例和对照血浆中维生素D水平，检测大肠癌病例手术切除标本BMP/Smad信号通路主要成分（BMPR1,2和Smad1,4,5,8）表达情况，探讨BMP/Smad信号通路在维生素D与大肠癌关系中的作用。同时，通过观察维生素D对大肠癌细胞株BMP/Smad 信号通路的调节作用，以及对细胞增殖和凋亡的影响，进一步在细胞学水平上验证维生素D、BMP/Smad信号通路与大肠癌发病之间的关系。研究结果有助于进一步阐明维生素D与大肠癌发病关系，从而为大肠癌相关预防控制策略和措施的制定提供进一步的科学依据。

Previous studies have shown that vitamin D, which can activate BMP/Smad signal pathway, was a protective factor of colorectal cancer. Since the inactivation of BMP/Smad signal pathway was associated with the risk for colorectal cancer, we proposed a hypothesis that vitamin D may reduce the risk for colorectal cancer by keeping normal activation of BMP/Smad signal pathway. In order to validate the hypothesis, we will conduct a case-case-control study to explore the relationship between Vitamin D, BMP-Smad signalling, and colorectal cancer by determining the plasma vitamin D status of all participations and the expressions of BMPR1,2 and Smad1,4,5,8 in colorectal cancer tissue specimens. Our result will produce evidence in the relationship between vitamin D and the risk for colorectal cancer, and provide the scientific evidence for the strategies and measures of the prevention and control of colorectal cancer.