癌症是威胁人类生命健康的主要杀手，目前传统的治疗方法在癌症诊断、监控和治疗过程中仍存在一定的局限性。因此，需要开发一种精准监控与靶向治疗为一体的癌症治疗手段以期实现癌症的有效治疗。但现阶段仍缺乏合适的药物平台和有效的监控方法。本项目拟以聚多巴胺修饰的二维黑磷纳米片为增强型光热治疗的基础平台，利用聚多巴胺表面丰富的氨基化学键合RGD多肽和荧光染料罗丹明B（rhodamine B, RB）、π-π堆积作用负载化疗药物阿霉素DOX，构建具有靶向化疗/热疗和光学成像功能为一体的杂化纳米药物。利用荧光寿命成像FLIM动态监测DOX引导的体外化疗过程和RB引导的体外热疗过程；利用光声成像PA动态监测体内肿瘤治疗过程。通过将治疗和实时监控有机结合，实时监测体外到体内的肿瘤治疗过程，实现诊疗一体化，为癌症的精准靶向治疗奠定重要的实验和理论基础，具有重要的研究意义。

Cancer has been a major killer of human life. However, there are various drawbacks in traditional therapeutic methods during the process of diagnosis, monitoring, and treatment of cancer. Therefore, it is urgent to develop a cancer treatment with precise monitoring and targeted treatment properties, to achieve effective cancer treatment. However, to date, no suitable drug platforms or effective monitoring methods have been developed. In this project, polydopamine (PDA) modified two-dimension black phosphorus nanosheets (BPNSs) were synthesized as an enhanced photothermal therapy agent. The formed PDA-BPNSs were then modified with targeted agent RGD peptide and fluorescent dye rhodamine B (RB) through chemical bonding, and loaded with an anticancer drug doxorubicin (DOX) through π-π stacking interaction to build a hybridized nanodrug with targeted chemo-photothermal therapy and optical imaging properties. Fluorescence lifetime imaging microscopy (FLIM) was used to monitor DOX related to the process of chemotherapy in vitro and RB related to the process of photothermal therapy in vitro in real time. Hereafter, in vivo treatment process was monitored by photoacoustic (PA) imaging in detail. Therefore, this project will organically combine cancer therapy with cancer monitoring to realize theranostics in vitro and in vivo. What’s more, the project will lay great experimental and theoretical groundwork for precise targeted cancer treatment, which shows a great research meaning.