Iron oxide nanoparticles as a drug carrier reduce host immunosuppression for enhanced chemotherapy.
Iron oxide nanoparticles as a drug carrier reduce host immunosuppression for enhanced chemotherapy.
复制标题
氧化铁纳米粒子作为药物载体减少宿主免疫抑制以增强化疗
作者：
化疗仍被认为是癌症治疗的主要方式。然而，它经常抑制宿主免疫系统，导致治疗效果有限。设计一种新的化疗药物来降低免疫抑制水平是很有必要的。在此，我们设计了牛血清白蛋白(BSA)-生物启发氧化铁纳米颗粒（IONPs）作为纳米载体，负载抗癌药物米托蒽醌（MTX）用于原位乳腺癌的强化化疗。IONPs@BSA-MTX复合物治疗组的CD3+CD4+和CD3+CD8+ T淋巴细胞明显高于游离MTX。该复合物能有效恢复宿主免疫系统，具有比游离MTX更好的抗癌效果。值得注意的是，bsa激发的IONPs是一种令人满意的肿瘤和淋巴结磁共振成像造影剂。我们的工作为乳腺癌和其他癌症治疗中低水平免疫抑制的强化化疗提供了一种新的策略。bsa -生物激发氧化铁纳米颗粒作为纳米载体装载抗癌药物米托蒽醌，用于低水平免疫抑制的强化化疗。
Chemotherapy is still regarded as the main modality for cancer treatment. However, it often suppresses host immune system, resulting in limited therapeutic effects. It is desirable to design a novel chemotherapeutic agent to reduce the level of immunosuppression. Herein, we designed bovine serum albumin (BSA)-bioinspired iron oxide nanoparticles (IONPs) as a nanocarrier to load anticancer drug mitoxantrone (MTX) for enhanced chemotherapy of orthotopic breast cancer. The IONPs@BSA-MTX complexes treatment increased much more CD3+CD4+ and CD3+CD8+ T lymphocytes than free MTX. The complexes effectively restored host immune system and produced a better anticancer efficacy than free MTX. It was worth noting that the BSA-inspired IONPs were a satisfactory contrast agent for magnetic resonance imaging of tumors and lymph nodes. Our work provides a novel strategy for enhanced chemotherapy with low levels of immunosuppression in the treatment of breast cancer and other cancers. BSA-bioinspired iron oxide nanoparticles as a nanocarrier to load anticancer drug mitoxantrone for enhanced chemotherapy with low levels of immunosuppression.
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