益生乳酸菌缓解有机磷农药中毒机制

农药污染已成为严重危害人体健康的食品安全问题，益生乳酸菌因具有降解农药特性备受关注。本项目以具有降解有机磷农药活性的益生植物乳杆菌P9为研究对象，通过有机磷农药慢性中毒大鼠模型系统评价该菌株的不同干预方式对宿主的靶器官、免疫系统、神经系统和肠道微生态的缓解作用，关联分析宿主生理生化、代谢物和肠道微生物的差异，综合揭示有机磷农药对大鼠肠道菌群和机体功能的影响，解析益生乳酸菌缓解有机磷农药中毒症状的作用机理，为益生乳酸菌在降解农药残留乃至慢性中毒方面提供理论基础。

Pesticide contamination and poisoning have become alarming food safety issues as they may endanger human health severely. Lactic acid bacteria possess natural pesticide degradation activities and are thus of potential to be applied in pesticide decontamination. This study aims to investigate the effects of Lactobacillus (L.) plantarum P9 in alleviating pesticide toxicity to host target organs, immune system, nervous system, and gut microbiome in a rat phorate poisoning model. By combining correlation analysis of modulations in the host physiology and biochemistry status, metabolome, and metagenome, this work also aims to explore the in vivo detoxifying mechanisms of L. plantarum P9, especially the role of the gut microbiome and function in the detoxifying process. Data obtained from this research would provide novel insights into the detoxifying mechanisms of lactic acid bacteria and are useful for future research and application of these bacteria in combating chronic pesticide poisoning.