Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts.
Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts.
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DOI：
10.1016/j.isci.2022.104472
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发表时间：
2022-07-15
期刊：
影响因子：
5.8
通讯作者：
Zhang, Heping
中科院分区：
文献类型：
--
作者：
Liu, Wenjun;Li, Changkun;Li, Bohai;Shang, Qingxiang;Han, Zhe;Zhang, Yuan;Liu, Xiufang;Fan, Hui;Zhang, Jiachao;Chen, Yongfu;Zhang, Heping
多种农药残留的累积增加了人类患慢性代谢性疾病的可能性。因此，我们应用多组学技术来揭示肠道微生物组对农药暴露的反应。然后，我们探讨了益生菌植物乳杆菌P9(P9)在高农药暴露后对肠道微生物区系和免疫因子的影响。多组学结果表明，频繁接触农药并没有改变肠道微生物区系的组成，但它确实增加了肠道内脂多糖的丰度，这可能导致慢性炎症。补充P9维持了肠道微生物区系的动态平衡，降低了高农药暴露受试者的病原体丰度。通过对代谢产物的检测，我们观察到服用P9后尿苷和5-羟脯氨酸浓度显著增加。此外，P9还能缓解免疫因子紊乱，促进农药残留排泄。我们的发现为益生菌在农药解毒中的应用提供了新的见解，并建议益生菌作为预防农药暴露的日常补充剂。高频农药暴露诱导炎症反应P9高农药暴露受试者维持肠道微生物区系平衡P9显着增加受试者有益代谢物水平P9降低炎症反应并促进农药残留排泄生物科学；微生物学
Multiple pesticide residue accumulations increase the probability of chronic metabolic diseases in humans. Thus, we applied multi-omics techniques to reveal how the gut microbiome responded to pesticide exposure. Then, we explored how probiotic Lactiplantibacillus plantarum P9 (P9) consumption impacted the gut microbiota and immune factors after high pesticide exposure. Multi-omics results indicated frequent exposure to pesticides did not alter the composition of the intestinal microbiota, but it did increase the abundance of Lipopolysaccharide in the gut, which might contribute to chronic inflammation. Supplementation with P9 maintained the homeostasis of the gut microbiota and reduced the abundance of pathogens in the high pesticide-exposed subjects. By detecting metabolites, we observed uridine and 5-oxoproline concentrations increased significantly after P9 consumption. Furthermore, P9 alleviated immune factors disorder and promoted pesticide residue excretion. Our findings provide new insights into the application of probiotics for pesticide detoxification, and suggest probiotics as daily supplements for pesticide exposure prevention. High-frequency pesticide exposure induced inflammatory responses to occur P9 maintained gut microbiota homeostasis in subjects with high pesticide exposure P9 significantly increased the level of beneficial metabolites in the subjects P9 reduced inflammatory response and promoted excretion of pesticide residues Biological sciences; Microbiology; Omics
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影响因子：
4
作者：
BROCK, A;BROCK, V
通讯作者：
BROCK, V
具有有机磷农药降解活性的植物乳杆菌菌株筛选及甲拌磷降解代谢组学分析
影响因子：
5.2
作者：
Li C;Ma Y;Mi Z;Huo R;Zhou T;Hai H;Kwok LY;Sun Z;Chen Y;Zhang H
通讯作者：
Zhang H
影响因子：
9.4
作者：
Domann, E;Hong, G;Chakraborty, T
通讯作者：
Chakraborty, T
影响因子：
4.2
作者：
Jerez-Morales A;Merino JS;Díaz-Castillo ST;Smith CT;Fuentealba J;Bernasconi H;Echeverría G;García-Cancino A
通讯作者：
García-Cancino A
DOI：
10.3390/ani10112144
发表时间：
2020-11-18
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Giraldi M;Paltrinieri S;Piazza C;Scarpa P
通讯作者：
Scarpa P