以光学相干层析成像(OCT)和光学相干血管成像（OCTA）为代表的新型眼底成像技术可提供微米尺度非接触式无创三维眼底结构和血流功能性成像，在各种眼底疾病诊疗中起着极其重要的作用。现有的OCTA三维眼底功能性成像技术受限于成像速度和系统的位相稳定性，难以同时用于视网膜中心和外周的成像，由此无法给出有助于早期发现和诊断大多数致盲性眼病的视网膜整体信息。本项目从突破制约眼底OCTA成像的瓶颈出发，研究实现超快眼底结构和功能性成像的原理与技术，重点研究超快扫描率高稳定性1060nm波长扫频光源的实现，包括傅里叶域锁模扫频光源的长期和短期扰动因素的研究，并通过动态补偿激光腔内的光程飘移和抑制光源的位相扰动，提升扫频光源的扫描率和位相稳定性；同时研究高灵敏度提取与处理OCT信号位相的方法和技术以提高OCT和OCTA成像质量。该项目的完成对推进先进诊疗特别是眼底疾病诊断新技术的发展有重要意义。

New fundus imaging techniques such as optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) have been widely applied in diagnosis and treatment of numerous retinal diseases owing to the capabilities of non-contact, non-invasive, micron scale 3D structural and functional retinal imaging. However, OCT and OCTA are hardly used to diagnose peripheral retinal diseases since the current techniques are limited by the imaging speed and the phase stability of the system. In this proposal, we plan to develop a swept source at a working wavelength of 1060 nm to overcome these bottlenecks. The stability and scanning rate of the Fourier domain mode locking (FDML) swept source will be improved by dynamically suppressing the phase drift and compensating the path-length shift of the light in the laser cavity. In addition, we propose to develop the techniques and algorithms to precisely extract and process the phase information of OCT signals for structural and angiographic imaging. The successful completion of the proposed research will have the potential to be developed as a novel technology for fundus disease diagnosis.