课题基金基金详情
基于类肝素植物多糖衍生物的复合生物功能化脂肪族聚酯材料的构筑及机理研究
结题报告
批准号:
21965016
项目类别:
地区科学基金项目
资助金额:
40.0 万元
负责人:
李辉
依托单位:
学科分类:
医用材料化学
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
李辉
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中文摘要
脂肪族聚酯是一类重要的生物医用高分子材料,但由于该类材料表面疏水且缺乏细胞识别的有效位点,致使生物相容性欠佳,限制了其在生物医用材料领域的有效应用。本项目选取来源广泛的植物多糖改性制备具有生物活性的类肝素植物多糖衍生物,通过层层自组装技术将其固定到脂肪族聚酯材料表面,以构筑兼具生物相容性和医用功能性的复合生物功能化聚酯材料。具体内容包括:通过不同的衍生化途径制备类肝素植物多糖衍生物,探讨其抗凝活性与结构的关系;采用不同的自组装方案将多糖衍生物固定到聚酯材料表面,研究多层膜的表面特性、成膜方式及成膜机制;考察不同多层膜对被修饰材料表面生物相容性和医用功能性的影响,揭示植物多糖衍生物结构与材料表面性能的关系。预期研究成果可为类肝素植物多糖衍生物用于脂肪族聚酯生物材料的表面修饰提供理论依据,为功能性脂肪族聚酯材料在人工植入物或与血液接触医用材料领域的应用提供基础支撑。
英文摘要
Aliphatic polyester is one of important biomedical polymer materials due to their excellent biodegrability, biosafty and physical-mechanical properties. However, their practical use is limited by their surface hydrophobic property and lacking of cell recognition sites, it is of much importance to improve surface biocompatibility of aliphatic polyester materials. In this proposal, bioactive heparin-like plant polysaccharide derivatives have been prepared and been immobilizied onto the surface of aliphatic polyester materials via layer-by-layer (LBL) self-assembly technique for the purpose of fabrication of composite biological functionalized aliphatic polyester materials surface, including both biocompatibility and some special medical functions. The study content as follows: (i) Heparin-like plant polysaccharides derivatives will be prepared using different modification methods, and the relationship between anticoagulation and polysaccharides structures will be discussed. (ii) The LBL multilayers will be constructed on polyester material surface using different LBL strategies respectively. Surface characters, growth manner and formation mechanisms of multilayers will be studied. (iii) The surface biocompatibility and biomedical functions of modified polyester material will be investigated, and the relationship between material surface property and polysaccharides derivatives structure will be explored. The study results of this proposal will provide important theoretical basis and application data for use of plant polysaccharides derivatives to modify the biomaterials, and the modified functional aliphatic polyester materials will have potential application in the field of implant materials, cardiovascular biomaterials and blood cotacting devices.
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DOI:10.1016/j.ijbiomac.2020.03.180
发表时间:2020-03
期刊:International journal of biological macromolecules
影响因子:8.2
作者:Ying Yu;Rongqi Cui;Xin Wang;Hao Yang;Hui Li
通讯作者:Ying Yu;Rongqi Cui;Xin Wang;Hao Yang;Hui Li
DOI:10.1016/j.ijbiomac.2023.123285
发表时间:2023-01
期刊:International journal of biological macromolecules
影响因子:8.2
作者:Kun Wang;Ying Yu;Wei Li;Da Li;Hui Li
通讯作者:Kun Wang;Ying Yu;Wei Li;Da Li;Hui Li
DOI:10.1016/j.ijbiomac.2022.09.243
发表时间:2022-09
期刊:International journal of biological macromolecules
影响因子:8.2
作者:Fuyou Yu;Hongbo Shi;Kun Wang;Hui Li;Lincai Peng
通讯作者:Fuyou Yu;Hongbo Shi;Kun Wang;Hui Li;Lincai Peng
DOI:10.1016/j.carbpol.2020.117156
发表时间:2021-01-15
期刊:CARBOHYDRATE POLYMERS
影响因子:11.2
作者:He, Yunqing;Li, Hui;Peng, Lincai
通讯作者:Peng, Lincai
DOI:10.1016/j.fbio.2022.101729
发表时间:2022-04
期刊:Food Bioscience
影响因子:5.2
作者:Hongbo Shi;Lin Wu;Yiding Luo;Fuyou Yu;Hui Li
通讯作者:Hongbo Shi;Lin Wu;Yiding Luo;Fuyou Yu;Hui Li
层层自组装增强及超疏水改性纸质包装材料及机理研究
  • 批准号:
    21566020
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    40.0万元
  • 批准年份:
    2015
  • 负责人:
    李辉
  • 依托单位:
国内基金
海外基金