类风湿性关节炎（RA）是一种最常见的慢性炎症性自身免疫疾病，虽然纳米载体的应用一定程度改善了药物治疗的不足，但其靶向治疗仍面临巨大挑战。本课题旨在构建一种“壳-核”型仿生巨噬细胞膜包被钩吻素子白蛋白自供氧纳米递送系统。该系统首先通过RA炎症病理特征释放的趋化因子与巨噬细胞膜的相互作用，被招募至病灶关节，从而增加药物蓄积。随后白蛋白纳米粒共转运钩吻素子和过氧化氢酶，催化炎症部位的过氧化氢产生氧气，改善RA缺氧微环境的同时，控制药物精准释放，实现药物和供氧的协同高效治疗。在优化构建载体及体内外系统评价的基础上，深入探讨仿生纳米粒免疫调节及其分子作用机制。该递药系统设计简单且高效，具有优良的生物相容性，可作为RA多靶点、多途径治疗的仿生载体，为探索新一代纳米载体治疗RA提供了一个合理且创新的方法。

Rheumatoid arthritis (RA) is one of the most common and severe autoimmune diseases related to joints. Although the application of nanocarriers has improved the deficiencies of drug therapy to a certain extent, its targeted therapy still faces huge challenges. This subject aims to build a macrophage membrane coated koumine-albumin self-oxygenating biomimetic drug delivery system. Through the interaction of chemokines released by the pathological features of RA and macrophage membranes, bionic nanoparticles are recruited to the RA joints, thereby increasing drug accumulation. Subsequent co-loaded catalase catalyzes the production of oxygen by hydrogen peroxide, improves the hypoxia microenvironment of RA, controls drug release, and achieves a synergistic and efficient treatment of drugs and oxygen supply. Based on the optimized construction of the carrier and in vivo and in vitro system evaluation, the immune regulation function of koumine-albumin nanoparticles and its molecular mechanism are discussed in depth. The drug delivery system is simple and efficient in design and has excellent biocompatibility, is an effective bionic carrier for multi-target and multi-channel treatment, and provides a reasonable and innovative method for exploring the new generation of nano-carriers for the treatment of RA.