本项目通过对信息、化学、材料、生命、医学的交叉研究，针对临床肝癌微波消融不彻底存在残余病灶与易转移复发的问题，提出了清除GSH增强微波电磁生物效应协同化疗联合治疗的策略。首先，利用纳米材料的EPR效应使MnMOF-Apa@PCM超颗粒被动靶向至肿瘤区域，在微波辐照下产生增强的电磁生物热效应，提高微波热疗的疗效；同时，产生微波电磁生物非热效应，而热效应刺激热响应开关PCM打开，继而肿瘤微环境中的GSH与MnMOF载体快速反应，清除肿瘤内的GSH，确保ROS发挥作用，增强电磁生物非热效应，辅助杀死残余病灶。在微波电磁生物热效应与肿瘤微环境双重响应控制下，药物在肿瘤内精准释放，有效提高靶向药物对新生血管的抑制作用，抑制术后转移复发。此外，降解产物Mn2+核磁成像，实时监测肿瘤治疗与药物释放。本研究为临床肝癌的微波消融治疗提供了新的材料和方法，为癌症的综合治疗提供新的生物电子学理论。

In this project, through the cross research of information, chemistry, materials, life and medicine, we proposed the novel strategy of removing GSH to enhance microwave electromagnetic biological effect in combination with chemotherapy to solve the problem of local lesion residual and tumor metastatic recurrence in clinic hepatocellular carcinoma after microwave ablation. First of all, MnMOF-Apa@PCM supernanoparticle is passively targeted to the tumor region by the EPR effect of nanoparticles in tumors, which can effectively convert microwave energy into heat energy under microwave irradiation, improve the temperature difference between tumor region and normal tissue, enhance the electromagnetic biological thermal effect and the therapeutic effect of microwave ablation. Meanwhile, the microwave electromagnetic biological nonthermal effect is generated to assist microwave thermal therapy, while the microwave thermal stimulation response switch PCM is turned on, then the GSH in the tumor microenvironment and MnMOF react quickly to deplete the GSH and ensure the ROS play a role at the same time, so as to enhance the microwave electromagnetic biological nonthermal effect and assist to kill the residual lesions of microwave thermal therapy. While under the response control of microwave electromagnetic biological thermal effect and tumor microenvironment, the drug is released precisely in the tumor region, effectively improving the inhibition effect of targeted drugs on new blood vessels and inhibiting postoperative metastasis and recurrence. Moreover, the degradation product of MnMOF, Mn2+, can be used for magnetic imaging to monitor the tumor treatment and drug release in real time. This study will provide new materials and methods for the treatment of local residual lesions after hepatocellular carcinoma mincrowave ablation, and provide new bioelectronics theories for the comprehensive treatment of cancer.