动态动力学拆分比传统拆分的优势在于其能使理论产率提高到100%，而结合动态动力学拆分和不对称催化的策略可以高收率地合成双或多手性中心化合物。该方法的主要瓶颈在于较难实现远程双或多手性中心的构建和控制。.本项目采用Retro-Michael/Michael加成和不对称氢转移的方法实现β-取代酮动态动力学拆分，试图来构建1,3-位双手性中心化合物。通过探讨β-取代酮底物基于Retro-Michael/Michael加成的消旋化过程，来突破在构建1,3-位双手性中心过程中反应收率低和非对映选择性差的瓶颈；通过优化消旋化和不对称氢转移二者协同反应过程来揭示构建双手性中心高对映选择性的规律和本质；通过选择不同结构类型的β-取代酮底物来实现各类型双手性中心的构建，解决底物适用性窄的缺陷，为丰富具有生物活性的1,3-位双手性化合物应用提供理论支撑和实验条件。

The theoretical yield of dynamic kinetic resolution is up to 100%. The methodology combining dynamic kinetic resolution and asymmetric catalysis can provide the compounds with two chiral centers or multichiral centers. The bottleneck of this method is remote chirality control. .In this project, we try to construct 1,3-chiral centers compounds based on retro-Michael/Michael addition and asymmetric transfer hydrogenation. The bottleneck of constructing 1,3-chiral centers compounds is low yield and poor diastereoselectivity, which will be broken by optimizing the racemization of β-substituted ketones using retro-Michael/Michael process. The regularity will be revealed by investigating the collaborative process of the racemization and asymmetric transfer hydrogenation. At last, we will synthesize a series of 1,3-substituted chiral molecules, which will be used for bioactive test.