雷公藤及其制剂在临床上有很好的治疗效果，但因其毒副作用而大大限制其临床应用。本课题在传统“相畏相杀”理论基础上，提出中药配伍“异类相制”减毒的新假说。甘草具有调和诸药和解毒的作用，大量临床实践和实验研究均证明了甘草“解百药毒”这一传统认识的科学性。我们前期课题研究发现甘草能诱导二相解毒酶UGTs和P-gp等外排转运体，Nrf2/ARE 信号转导通路是当前研究热点，它主要负责调控许多与氧化应激酶、解毒酶和外排转运体相关基因的表达。为此，我们提出假说：基于Nrf2/ARE信号通路探讨甘草抵御雷公藤肝毒性的“异类相制”减毒机制研究。为验证这一假说，我们将从药物代谢动力学角度，结合分子生物学、组织形态学、转基因技术和代谢组学技术，从分子、细胞以及动物整体水平等多方面研究甘草配伍雷公藤减毒增效的物质基础及其作用机制，为雷公藤的临床配伍用药提供科学依据，为寻找提高中药复方安全性和有效性提供新的思路。

Lei Gong Teng(Triptergium wilfordii)and its preparations have very good curative effect in clinic, The clinical uses are restricted due to the side effects from the toxicity of this substance. This study prosed a new hypothesis “mutual inter-control” of herbal compound detoxicity by compatibility,which is based on the traditional theory of “mutual restraint and detoxication”. Licorice has to reconcile the various drugs and detoxification role, a large number of clinical practice and experimental research show that licorice relieve various kinds of drug toxicity of this traditional understanding of science. Our previous study found that licorice can induce phase Ⅱ detoxification UGTs and P-gp efflux transporter, Nrf2/ARE are signal transduction pathway is the focus of current research. It is mainly responsible for associated gene expression of the kinase, drug metabolizing enzymes and efflux transporter .Therefore, we put forward the hypothesis: Based on the Nrf2/ARE signal pathway of licorice against liver toxicity of Tripterygium wilfordii " mutual restraint and detoxication " attenuated mechanism research. To test this hypothesis, we will from the point of view of drug metabolism and pharmacokinetics, combined with molecular biology, transgenic technology and Metabonomics, reduction from the molecular, cellular and whole animal levels in many aspects of Glycyrrhiza compatibility Tripterygium wilfordii to the toxic mechanism, to explore the signal transduction kinase and detoxifying enzymes and stress kinase for the connection and rule between the transporter, for improving the safety and effectiveness of traditional Chinese medicine compound to provide new ideas.