阿尔茨海默病（Alzheimer's Disease, AD）已成为威胁老年人身体健康的主要疾病，但目前缺乏有效的治疗药物。寻求促进海马成体发生及激活脑源性神经营养因子（BDNF）通路的药物或方法，用来治疗神经系统疾病特别是AD已成为目前的研究热点。多种补肾、活血中药的单体或提取物可通过以上机制发挥轻度的抗AD作用。补肾祛瘀化痰复方能有效缓解AD患者症状，其机制可能是中药复方强化了海马成体发生及BDNF的神经保护效应，并减少淀粉样蛋白（Aβ）沉积。本研究采用补肾化痰祛瘀中药复方，从原代海马神经元细胞、AD动物模型2个层次，从成体海马神经发生、BDNF/TrkB神经营养信号通路、Aβ沉积3个方面探讨补肾化痰祛瘀方的抗AD疗效及现代医学作用机制。同时，进一步提取该复方的有效成分，评估各有效成分的药效及药代动力学，希望为轻、中度AD患者的治疗提供新策略。

Alzheimer's Disease（AD）is one of the most common cause of death in the eldly, whereas no effective drugs to stop the disease progression. Hippocampal neurogenesis and brain-derived neurotrophic factor (BDNF) were showed to have neuroprotective effects. Several extracts from Bu-Shen or Qu-Yu herbs have mild anti-AD effect by the above mechanisms. Bu-Shen Qu-Yu Hua-Tan decoction played better benifits on AD patients, one explain might be the compounds of herbs magnify the neuroprotection of hippocampal neurogenesis and BDNF signal pathway. The present study will investigate the effect of Bu-Shen Hua-Tan Qu-Yu decoction on AD in primary neuronal cell or AD animal model. We will evaluate the mechanisms of the decoction on hippocampal adult neurogenesis, the signaling pathway of neurotrophic factor BDNF/TrkB, and amyloid-β peptide hypothesis in two AD models in vivo and in vitro. Meanwhile, the constituents from Bu-Shen Qu-Yu Hua-Tan decoction will be extracted, the medicinal effects and pharmacokinetics of the constituents will be evaluated. The project is going to firstly eluciate the role(s) and the mechanism(s) of the herbs therapy on adult neurogenesis and to verify that it is a novel, mutitarget and cheap strategy for mild and moderate AD patients.