在我们前期工作的基础上，借鉴前人有关贵金属纳米粒子手性的研究成果，本项目拟以贵金属纳米粒子内在手性为基础，利用溶液法合成出不同形貌的金纳米粒子、银纳米粒子、金-银双金属纳米粒子，对所得粒子晶体结构、表面组成、粒径尺寸等进行结构表征，同时用圆二色谱对各种形貌纳米粒子的手性进行表征，研究纳米粒子结构与其手性之间的关系，探索影响贵金属纳米粒子内在手性的因素，揭示其内在手性产生机制；用微量热法、变温核磁等手段研究手性分子与纳米粒子的相互作用过程，揭示贵金属纳米粒子手性识别机理；将贵金属纳米的手性识别与其表面等离子体共振吸收、圆二色性相结合，构筑分子识别与信号转导一体化的纳米探针，揭示纳米手性传感的响应机理，建立高效的手性传感新方法。本项目将贵金属纳米粒子的内在手性用于手性识别，给人们设计纳米手性传感提供一种新的思路。同时，本项目也将丰富纳米结构手性的研究内容，推动手性科学向纵深发展。

On the basis of the previous researches on the chirality of noble metal nanoparticles, this project will aim to make full use of the intrinsic chirality of noble metal nanoparticles to construct the chiral sensing. We will synthesize gold nanoparticles, silver nanoparticles and gold-silver bimetallic nanoparticles with different morphologies, and characterize the crystal structure, surface composition and particle size of the obtained particles. The chirality of metal nanoparticles with various morphologies will be characterized with circular dichroism spectroscopy, and the relationship between the structure of nanoparticles and their chirality will be systematically studied. The factors affecting the chirality of noble metal nanoparticles will be explored, and the mechanism of intrinsic chirality will be revealed. The interaction between chiral molecules and the nanoparticles will be studied through the microcalorimetry and temperature-dependent nuclear magnetic resonance to reveal the chiral recognition mechanism of nano-meter particles. On the other hand, combining the chiral recognition of noble metal nanoparticles with their surface plasmon resonance absorption and circular dichroism, we will suggest a nano-probe integrated with molecular recognition and signal transduction to establish an efficient chiral sensing method. In this project, the intrinsic chirality of noble metal nanoparticles is used for chiral recognition, which provides a new idea for the design of nano-chiral sensors. At the same time, this project will enrich the research content of chirality of nanostructures and promote the development of chirality science.