电离辐射诱导的长链非编码RNA通过机械力传导通路调控肿瘤增殖/转移的研究

批准号:
31971165
项目类别:
面上项目
资助金额:
58.0 万元
负责人:
畅磊
依托单位:
学科分类:
细胞感应与环境生物物理
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
畅磊
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中文摘要
细胞通过力学感受器接收外界物理力学信号,并由细胞骨架系统产生相对应的细胞内部物理力学系统和信号传递系统。细胞力学系统失调会导致包括肿瘤在内的多种疾病。我们的前期工作揭示了机械力传导通路的开关分子SWI/SNF调节YAP/TAZ 的活性,进而影响细胞的增殖和癌变。.以碳重离子放疗为代表的新型放射疗法在临床实践中取得了令人瞩目的成绩,然而其背后的生物学机制我们还不甚了解。在前期工作中我们发现了受碳重离子辐射诱导的LNC CRYBG3能够调控肌动蛋白组装,并且具有抑癌功能。结合前期工作我们提出:LNC CRYBG3是否作为连接电离辐射和生物力学传导通路的纽带,通过调节生物力学传导通路效应分子YAP/TAZ的活性来调控肿瘤的增殖和侵袭转移。据此,我们提出“电离辐射-->LNC CRYBG3 --|F-actin --|SWI/SNF --|YAP/TAZ-->肿瘤增殖、侵袭转移”调控机制的假说。
英文摘要
Cells receive multiple levels of mechanic force, from cell-cell contact level to tissue level. The receptor from cell membrane can pass this message though mechanotransduction pathways. It has been well recognized that miss regulation of mechanotransduction can cause many diseases or even cancer. Previously, we have reported that the SWI/SNF complex is a mechanoregulated inhibitor of YAP/TAZ. Mutation of SWI/SNF could disrupt mechanotransduction and induce cancer formation..On the other hand, it is remarkable that the radiation-therapy, especially by using heavy irons, have significant outcome from surgery of cancer therapy. As new generation of radiation-therapy, accelerated carbon beams have several advantages and better prognosis. But the mechanism is still mystery. In our previous research, we found a long non coding RNA (LNC CRYBG3) is induced by accelerated carbon beams. Overexpression of LNC CRYBG3 could block formation of F-actin, changing the cytoskeleton system. In vivo experiments, we fund that LNC CRYBG3 plays inhibitor role during cancer development. Then we asked, if it is possible that LNC CRYBG3 serves like a bridge link the iron radiation (IR) to mechanotransduction? Following this idea, we propose a new pathway : “IR-->LNC CRYBG3 --| F-actin --| SWI/SNF --| YAP/TAZ”.
期刊论文列表
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专利列表
DOI:(2024) 10:68 ; https://doi.org/10.1038/s41420-024-01846-2
发表时间:2024
期刊:Cell Death Discovery
影响因子:7
作者:Ying Ye;Wenyan Xie;Zhaoru Ma;Xuepeng Wang;Yi Wen;Xuemei Li;Hongqian Qi;Hao Wu;Jinnan An;Yan Jiang;Xinyi Lu;Guokai Chen;Shijun Hu;Elizabeth A. Blaber;Xi Chen;Lei Chang;Wensheng zhang
通讯作者:Wensheng zhang
DOI:10.1007/s42764-022-00086-x
发表时间:2022-10
期刊:Genome Instability & Disease
影响因子:--
作者:Lijun Zheng;Mintao Ji;H. Zhang;L. Chang
通讯作者:Lijun Zheng;Mintao Ji;H. Zhang;L. Chang
DOI:doi.org/10.1038/s41467-023-39009-z
发表时间:2023
期刊:nature communications
影响因子:--
作者:Mintao Ji;Dongsheng Chen;Yinyin Shu;Shuai Dong;Zhisen Zhang;Haimeng Zheng;Xiaoni Jin;Lijun Zheng;Yang Liu;Yifei Zheng;Wensheng Zhang;Shiyou Wang;Guangming Zhou;Bingyan Li;Baohua Ji;Yong Yang;Yongde Xu;Lei Chang
通讯作者:Lei Chang
DOI:10.1038/s41419-022-04650-x
发表时间:2022-03-04
期刊:Cell death & disease
影响因子:9
作者:Zheng L;Luo C;Yang N;Pei H;Ji M;Shu Y;Zhang Z;Dong S;Wang X;Li X;Zhang W;Wang Y;Li B;Hei TK;Zhou G;Chang L
通讯作者:Chang L
DOI:10.1016/j.radmp.2023.10.006
发表时间:2023-10
期刊:Radiation Medicine and Protection
影响因子:--
作者:Hong Zhang;Yinyin Shu;Mintao Ji
通讯作者:Hong Zhang;Yinyin Shu;Mintao Ji
生物力学传导通路mechano-YAP/TAZ对放射损伤引起的勃起功能障碍中组织再生和功能修复的研究
- 批准号:82373525
- 项目类别:面上项目
- 资助金额:49万元
- 批准年份:2023
- 负责人:畅磊
- 依托单位:
电离辐射通过YAP/TAZ和SWI/SNF复合物调控早期胚胎发育的研究
- 批准号:--
- 项目类别:面上项目
- 资助金额:55万元
- 批准年份:2021
- 负责人:畅磊
- 依托单位:
国内基金
海外基金
