聚肽是以多肽为主链的聚合物，因其具有良好的生物相容性及可降解性，已成为重要的生物医药材料。本项目针对α-氨基酸-N-羧基酸酐( N-carboxyanhydrides，NCA) 开环聚合制备长链聚肽过程中步骤繁琐，反应条件苛刻，副反应多，聚合物微观结构（链化学组成，拓扑结构，链末端基，分子量，分子量分布等）难控制等科学问题开展研究，发展高效、绿色和精确的聚肽及聚肽杂化材料合成新方法、新策略和新催化体系，以期突破国外聚肽类材料合成催化体系的专利垄断，开发具有自主专利权的新型可控聚合催化体系，为新型聚肽类材料的合成提供理论指导。通过新型催化体系的开发、聚合引发剂和聚合单体的设计，实现α-氨基酸-N-羧基酸酐聚合与多种聚合方法（如可控自由基聚合，环酯配位聚合等）的有效结合，创制（非仿制）新型聚肽及聚肽杂化聚合物材料，为聚肽类材料的结构与性能研究提供理论基础。

Polypeptide has been one of the very important materials in biomedical field due to their excellent biocompatibility and biodegradability. This project will focus on the precise synthesis of polypeptides and polypeptide hybrids. In order to solve the existing problems of polypeptide synthesis, such as complicated procedure, harsh reaction conditions, more side reactions and difficulty of controlling microstructure of obtained polypeptides (such as main chain chemical composition, topology, chain end fidelity, molecular weight and molecular weight distribution), we will try our best to develop new strategies and metal-free catalytic systems to prepare polypeptides and polypeptide hybrids in green, fast and precise ways. The new methods will break through the existing patent constraint and provide new ways for the polypeptide synthesis for our country. Furthermore, by designing novel initiators and monomers, we will combine NCA polymerization with other current polymerization techniques such as controlled free radical polymerization, coordination ROP of cyclic esters to develop new strategies, providing new kinds of polypeptide based materials for the structure-property investigations.