基于计算解剖学的高度化的胰腺癌CAD技术的研究

现阶段计算机辅助诊断(CAD)的性能不如医生，主要原因在于计算机难以结合人体解剖结构进行图像诊断。特别是对于预后效果最差的胰腺癌，由于从医学图像中分割出胰腺的难度最大，使得胰腺癌CAD成为难题。近年国际上新兴的计算解剖学，旨在构建能描述个体差异极大的解剖结构的计算解剖模型，并基于该模型进行辅助诊断，形成高度化的CAD技术，大幅地提高CAD整体性能。本课题基于医学图像处理和统计学理论构建包含3D形状模型和状态模型的胰腺计算解剖模型，从该模型获得胰腺结构信息，研究基于胰腺计算解剖模型驱动下的胰腺分割、异常部位检测、特征提取和胰腺癌诊断新方法，建立胰腺癌CAD系统原型，在胰腺计算解剖模型和高度化的胰腺癌CAD关键技术方面取得突破，丰富计算解剖学的理论和方法，获得具有自主知识产权的高度化的胰腺癌CAD技术。此研究将计算解剖学引入到CAD中，蕴含着大量的新理论和新方法，具有重要的理论意义和应用价值。

Currently, the computer-aided diagnosis (CAD) can not perform as well as doctors because it is difficult for computer to combine diagnostic imaging with the human anatomy model. Especially for the diagnosis of pancreatic cancer which generally has the worst results after it is diagnosed, its difficulty of segmenting pancreas from medical image makes the CAD of pancreatic cancer a hard and active area of research. In recent years, the computational anatomy was developed to build the anatomical structure model for describing the human's great individual differences in anatomical structure, then carry out aided diagnosis based on the model, and finally produce a high performance CAD technology in order to greatly improve the overall performance of CAD technology. The subject tends to build the pancreas anatomical model based on the medical image processing and statistical theory, which include 3D shape model and state model, to adopt the pancreatic structural information from the anatomical model, and develop the novel methods of pancreas segmentation, abnormal sites detection, feature extraction and pancreatic cancer diagnosis based on the pancreatic anatomic model, and build pancreatic cancer CAD system prototype, try to have a breakthrough both on the computational anatomic model and the key technologies of high performance CAD for pancreatic cancer, enrich the theory and method of computational anatomy and lead to high performance CAD technology for pancreatic cancer with independent intellectual property rights. By introducing the computational anatomy into CAD, the research contains many novel theories and methods with significant theoretical meaning and practical value.