CA166-9 是我们新近克隆获得的、由我中心研制的卵巢癌单克隆抗体COC166-9 特异识别的抗原。生物信息学和生物学功能等初步研究发现该抗原为人免疫球蛋白样分子，阳性表达该抗原的卵巢癌细胞，具有显著的迁移性与侵袭性，而抗CA166-9 抗体可明显抑制该种癌细胞的迁移与侵袭，并发现该抗原是判断卵巢癌病人预后的独立危险因素，提示CA166-9 在卵巢癌发生发展中起重要作用。本项目拟在上述工作的基础上，在体外系统对CA166-9 的生物学功能进行研究；为后续进一步进行体内生物学功能研究、相关机制（如CA166-9 的相互作用蛋白、相关信号通路及活性调控等）及探讨其在小鼠体内作为疫苗预防和治疗卵巢癌的可行性提供理论基础。

We have recently cloned a new ovarian cancer associated antigen, which is specifically identified by COC166-9 monoclonal antibody against ovarian cancer. The preliminary bioinformatics and biological functions experiments revealed that CA166-9 is a human immunoglobulin-like molecula.Migration and invasion activities were evident in CA166-9 positive ovarian cancer cells and cells treated with the antigen,while COC166-9 monoclonal antibody could inhibit the migration and invasion in CA166-9 positive ovarian cancer cells.It was demonstrated that CA166-9 was an independent potential diagnostic and prognostic marker for ovarian cancer and might play an important role in ovarian cancer carcinogenesis and development. Based upon the above fundamental work, we would like to further systematically study the biological functions of CA166-9 both in vitro, in order to explore its biological functions in vivo,its molecular mechanisms and its feasibility as a vaccine for preventing or treating ovarian cancer in mounse models bearing ovarian cancer with normal immune system in later research.