痉挛型脑瘫是最常见的脑瘫类型，多伴有手功能障碍，导致患儿在发育的关键时期无法通过手获得足够的感官经验，严重者丧失生活自理能力。早期干预有助于改善预后，手功能分级是选择适宜干预措施的重要依据。然而，手功能分级的评估仍需在1岁以后。在新生儿期预测手功能分级已成为迫切需求，其核心问题是“手功能分级与早期脑损伤的映射关系是什么”。鉴于此，在前期构建的影像数据库基础上，本项目拟1）通过新生儿脑磁共振成像（MRI）,利用卷积神经网络实现病灶的自动化检测；2）联合T1加权、T2加权与扩散峰度成像对脑形态学与微结构属性进行量化分析，并通过脑图谱仿射与空域分析实现脑结构属性改变的精准定位；3）基于新生儿脑MRI特征与随访的手功能分级，使用病灶-症状映射方法揭示痉挛型脑瘫手功能分级与新生儿脑损伤多参量特征的映射关系。本研究有望推进对痉挛型脑瘫手功能分级的预测，为早期干预措施的选择提供依据。

Spastic cerebral palsy (SCP) is the most common type of cerebral palsy. Manual ability deficits can be frequently found on SCP patients. These patients lose the chance to learn knowledge through the perception by hands during the early development. The severe ones will lose the self-care ability in daily life. Early interventions based on manual ability levels will improve the prognosis. However, the assessment of manual ability levels would be accomplished typically after the age of 1 year. It is urgently necessary to predict manual ability levels of SCP during the neonatal period. Therefore, this project tries to solve the key problems for mapping the relationship between manual ability levels and brain lesions by using the neonatal magnetic resonance imaging (MRI). Based on the local MRI database, main contents of this project are arranged as follows: 1) Image segmentation will be performed by using the convolutional neural networks to detect brain lesions on neonatal MRI images. 2) This project will analyze structural alterations associated with brain lesions by combing T1 weighted imaging, T2 weighted imaging, and diffusion kurtosis imaging. Registration of brain atlas and fiber-tract quantification will be performed to characterize the spatial distribution of structural alterations. 3) Based on neonatal MRI features and the follow-up outcomes of manual ability levels, multivariate lesion-symptom mapping will be performed to reveal the relationship between manual ability levels and neonatal brain lesions. This project will improve the prediction of manual ability levels of SCP and provide evidences for the choice of early interventions.