基于磁共振应变分析及体表心电成像技术对冠心病缺血心肌的无创评估及精准定位

冠心病发病率高、危害大，冠心病患者的预后并非单纯取决于冠脉狭窄程度而更重要的是取决于缺血心肌是否存活，挽救存活的缺血心肌才是冠心病治疗的关键之一。因此，检测存活的缺血心肌意义重大。目前冠心病评估心肌缺血及其活性的手段多样，如冠状动脉造影、心肌核素成像等，但均存在一定的局限性及有创性。心肌一旦缺血，其运动及电生理状态都将发生改变。本项目拟利用心脏磁共振应变分析技术与体表心电图成像技术，将获得的心肌运动信息与心电信息相整合，以心肌梗塞动物模型及临床病例研究验证两者的相关性，最终形成一种应变-心电一体化的评估系统。本项目的研究成功，将真正实现对缺血心肌的精准定位及无创性评估，从而提高冠心病的诊疗与预后评估水平。

Coronary artery disease (CAD) is a severe health hazard with increasing morbidity and high mortality. The prognosis of patients depends on the degree of myocardial ischemia and myocardial viability. One of the decisive factors of coronary heart disease treatment is to save the ischemic but viable myocardium. Therefore, the detection and differential diagnosis of the ischemic myocardium become significant. There are many ways to assess myocardial ischemia and myocardial viability, including coronary angiography (CAG), single photon emission computed tomography (SPECT), and positron emission tomography (PET), but there are limitations and harmfulnesses. Once the myocardium ischemia exists, its movement and electrophysiological state will change. This project intends to use cardiac magnetic resonance (CMR) strain technology and noninvasive electrocardiographic imaging (ECGI) to obtain the information of myocardial motion and electrophysiology and to integrate them. We are trying to use an animal model of myocardial infarction and clinical case study to explore the correlation between the two kinds of information of myocardium. If we succeed, we can truly realize the goal of noninvasive assess and precise positioning of ischemic myocardium, thereby improving the diagnosis and prognosis of CAD.