轻度认知障碍患者（MCI）是发展为痴呆的高危人群。恰当的认知训练可以延缓MCI的认知能力下降，提高其生活质量，减少向老年痴呆转化的风险，这对应对我国目前和今后30多年严峻的人口老龄化形势有极其重要的意义。以往研究发现MCI的联结记忆（典型的情节记忆）比项目记忆损伤更大，并将此归结为MCI的“绑定”能力受损，忽视了MCI的语义记忆损伤。MCI情节记忆的干预研究，也忽视了其语义损伤，导致他们不能更高效的使用“绑定”策略。项目拟通过调节情节记忆过程中的语义信息，来研究MCI的语义记忆损伤对其情节记忆的影响及其神经机制，进而探索语义记忆训练是否能提高MCI患者的情节记忆能力，以及相应的神经机制。本项目在MCI记忆训练领域开创了一个全新的视角——通过训练语义记忆来帮助MCI更好的使用情节记忆编码策略。这是对目前最常用的“绑定”训练策略的重要补充，对目前MCI认知康复训练有极其重要的指导意义。

Patients with mild cognitive impairment are the high-risk people who may convert to Alzheimer’s Disease (AD). Proper cognitive training can keep their cognitive function, improve their living quality, and reduce the risks to AD. It is of particular importance for the coping of the severe aging situation in our country. Previous studies found that MCI is more impaired in associative memory than in item memory. This was attributed to their deficit ability of "binding", while their impairment in semantic memory was largely neglected. In this study, we will investigate the effect of semantic memory deficit on episodic memory, and the underlying neural mechanism. Furthermore, we will investigate the effect of semantic memory training on episodic memory, and the neural mechanism underlying the training. This study opens a new perspective for the memory training of MCI: to enhance the episodic memory of MCI through improving the memory strategies with semantic memory training. It is an important supplement for the current training strategy of "binding", and is very important for the cognitive training in MCI.