Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task.
Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task.
复制标题
在执行功能任务期间改变轻度认知障碍背景网络的远程同步
DOI：
10.3389/fnbeh.2017.00174
复制
发表时间：
2017
影响因子：
3
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Wang P;Li R;Yu J;Huang Z;Yan Z;Zhao K;Li J
迄今为止，很少有研究调查轻度认知障碍（MCI）患者依赖于执行功能的认知状态的背景网络。使用中心度（DC）指标，我们探索了混合延迟匹配样本任务（DMST）期间 MCI 背景网络的远程同步，该任务主要依赖于执行功能的工作记忆组件。我们在双侧后扣带皮层（PCC）和楔前叶腹侧亚区域观察到群体和认知状态之间存在显着的相互作用。对于正常对照组（NC）组，PCC/楔前叶与大脑其他区域的长距离功能连接（FC）在休息状态下高于工作记忆状态。然而，对于 MCI 患者来说，这种模式发生了变化。休息和工作记忆状态之间没有显着差异。在位于右角回的另一个簇中观察到类似的模式。为了检查PCC/楔前叶和角回的异常DC是否部分是由于这些区域与全脑其他部分之间的FC缺陷所致，我们以这些区域为种子进行了基于种子的相关性分析。结果表明，NC 参与者的双侧 PCC/楔前叶和右顶下小叶 (IPL) 之间的 FC 从休息状态到工作记忆状态有所增加。然而，对于 MCI 患者，休息和工作记忆状态之间没有显着变化。右角回和右前岛叶之间的 FC 也观察到类似的模式。然而，MCI 组和 NC 组在全局效率和模块化方面没有差异。这可能表明 MCI 患者的大脑网络缺乏从休息状态到工作记忆状态的有效重组。本研究表明，在依赖执行功能的任务中，MCI 背景网络的远程同步发生了改变。这些结果为MCI患者执行功能缺陷的神经机制提供了新的视角，并扩展了我们对任务诱发认知状态下大脑模式的理解。
Few studies to date have investigated the background network in the cognitive state relying on executive function in mild cognitive impairment (MCI) patients. Using the index of degree of centrality (DC), we explored distant synchronization of background network in MCI during a hybrid delayed-match-to-sample task (DMST), which mainly relies on the working memory component of executive function. We observed significant interactions between group and cognitive state in the bilateral posterior cingulate cortex (PCC) and the ventral subregion of precuneus. For normal control (NC) group, the long distance functional connectivity (FC) of the PCC/precuneus with the other regions of the brain was higher in rest state than that working memory state. For MCI patients, however, this pattern altered. There was no significant difference between rest and working memory state. The similar pattern was observed in the other cluster located in the right angular gyrus. To examine whether abnormal DC in PCC/precuneus and angular gyrus partially resulted from the deficit of FC between these regions and the other parts in the whole brain, we conducted a seed-based correlation analysis with these regions as seeds. The results indicated that the FC between bilateral PCC/precuneus and the right inferior parietal lobule (IPL) increased from rest to working memory state for NC participants. For MCI patients, however, there was no significant change between rest and working memory state. The similar pattern was observed for the FC between right angular gyrus and right anterior insula. However, there was no difference between MCI and NC groups in global efficiency and modularity. It may indicate a lack of efficient reorganization from rest state to a working memory state in the brain network of MCI patients. The present study demonstrates the altered distant synchronization of background network in MCI during a task relying on executive function. The results provide a new perspective regarding the neural mechanisms of executive function deficits in MCI patients, and extend our understanding of brain patterns in task-evoked cognitive states.
登录
查看更多内容
影响因子：
3.2
作者：
Kennett, S;Eimer, M;Driver, J
通讯作者：
Driver, J
影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
影响因子：
2
作者：
Klekociuk, Shannon Z.;Summers, Mathew J.
通讯作者：
Summers, Mathew J.
影响因子：
4.8
作者：
Lou, Wutao;Shi, Lin;Lam, Linda C. W.
通讯作者：
Lam, Linda C. W.
影响因子：
1.9
作者：
Migo, E. M.;Mitterschiffthaler, M.;Morris, R. G.
通讯作者：
Morris, R. G.