金属-酶超分子是自然界的普遍现象，在生物体内负责催化重要的生物过程，如光合作用、呼吸作用、水氧化、分子氧还原和固氮作用。然而,自组装金属-酶超分子用作有机合成催化剂的研究才刚刚起步;不对称C-C键的构建是有机合成永恒的主题，发展新型的构建不对称C-C键的催化剂仍是当前有机合成的主旋律。本项目拟以不对称C-C键的构建为目标，开展金属导向的酶自组装超分子催化剂的研究。项目拟首先建立构建C-C键的模型反应，并以其作为评价超分子催化剂的标准；金属导向的酶超分子的自组装；基于评价标准的高通量筛选金属-酶超分子催化剂；催化剂的优化、结构特性及自组装机理的研究；不对称反应研究；进而探索超分子催化剂的催化机理。本项目的研究旨在建立金属导向的自组装金属-酶超分子作为催化剂构建不对称C-C键的方法学；揭示金属-酶超分子催化剂的催化机理；拓展酶的用途和超分子化学的研究范围，丰富新的不对称催化剂的种类。

Metal-enzyme supermolecule is a common phenomenon in nature, which is responsible for catalyzing important biological processes, such as photosynthesis, respiration, water oxidation, molecular oxygen reduction and nitrogen fixation. The research of self assembled metal-enzyme supermolecule as catalysts is at its early stage. And the construction of asymmetric C-C bond is the eternal theme of organic chemistry. The development of novel catalysts for the formation of C-C bond is still an important research topic in organic synthesis. The goal of the proposal is to develop new self assembled metal-enzyme supermolecules as catalysts for the construction of asymmetric C-C bond.The following sections are going to be discussed in this project: Choose the typical model reactions of construction of C-C bond; Self-assemble supramolecules as catalysts; High-throughput screen self-assembled metal-enzyme supramolecular catalysts using the model reactions; Select the catalysts with high reactivity and stereoselectivity for further investigation; Develop the methodology for constructing asymmetric C-C bond; Explore the catalytic mechanism of supramolecular catalysts. The aims of this project: (1)To establish the methodology of construction of asymmetric C-C bond catalyzed by self assembled metal-enzyme supramolecular catalysts; (2)To reveal the mechanisms of metal-enzyme supramolecular catalysts; (3)To expand the scope of application of enzymes and supramolecular chemistry; (4)To increase the novel types of asymmetric catalysts for organic synthesis.