注意网络是负责基本认知行为—注意—的核心脑网络结构。课题组和其他团队前期研究发现COMT Val158Met基因多态性会调控注意行为及注意网络的正常组构。另外，早期失明会引起非视觉注意能力的代偿及注意网络的重塑。然而，COMT基因多态性对早盲注意网络重塑的调控作用还不清楚。本研究利用功能磁共振成像技术，系统研究COMT Val158Met基因多态性及其甲基化水平对早盲听觉注意认知代偿及其注意网络重塑的调控作用，并尝试阐明COMT基因多态性->早盲注意网络重塑->听觉注意认知代偿的通路机制。本研究将有助于理解早盲注意认知代偿及注意网络重塑的神经机制，为注意缺陷相关疾病的早期识别与干预提供重要线索。

Attention networks are the core networks responsible for the basic cognitive behavior, attention. Our previous research and several other studies have shown that COMT Val158Met gene polymorphism can regulate attention and normal organization of attention networks. Moreover, early visual deprivation can induce non-visual compensations and reorganization of attention networks. However, the regulatory role of COMT gene polymorphism in reorganization of attention networks is still unclear. This study will investigate the modulatory effect of COMT gene polymorphism and methylation in auditory cognitive compensation and reorganization of attention networks in the early blind by using functional MRI, and further illustrate the association among gene polymorphism, reorganization of attention networks, and non-visual cognitive compensations. The study will help to understand the neural mechanism of non-visual compensations and reorganization of attention networks, and to provide valuable cues for early identification and intervention for attention deficit related disorder.