高海拔低氧环境促使机体产生生理应激，并妨碍认知功能。这种认知功能的受损可能与海拔高度以及驻留时间密切相关。本项目针对从低海拔地区移居到西藏的汉族移民，采用行为和事件相关脑电位技术，开展高海拔缺氧对执行功能的影响及其神经机制的系列研究，尤其关注这种影响如何随着驻留海拔高度（空间维度）和时间而发生动态变化。在空间维度上，对比不同海拔居民（2700、3700、4500米）的执行功能特点，确定高海拔缺氧对执行功能影响的海拔梯度效应。在时间维度上，根据驻留时间分成急性、亚急性、完全适应、长期适应四个维度，通过追踪研究，确定高海拔缺氧对执行功能影响的时间累积效应及适应机制；本项目的研究成果可望为高海拔低氧环境适应性提供科学的测评指标，并为构建高海拔环境的脑适应理论做出贡献，为相关军民两用政策提供建议。

High altitude hypoxia induces physiological stress, which influences the cognitive function. The cognition impairment may related to the altitude and the dwell time. This project is aimed at immigrants from the low altitude place to Tibet, using cognitive behavior and event related brain potential (ERP) technique to explore the effects of high altitude hypoxia on executive function and their neural mechanism. In particular, it will concern with how this influence changes with the altitude (spatial dimension) and dwelling time. In the space dimension, by comparing the characteristics of executive funciton at different altitudes (2700, 3700, 4500 m), altitude gradient effect was confirmed. In the time dimension, longitudinal study was conducted to investigate the time cumulative effects of executive function impacted by the high altitude. The implementation of this project is expected to make the executive function as the indicator of the adaptation of the high altitude hypoxia, propose a new brain adaptation theory in high altitude environments and provide civil and military policy proposal.