硼中子俘获治疗（BNCT）是基于细胞水平的二元靶向放射治疗技术，在治疗恶性肿瘤方面具有独特的优势。含硼药物是实现BNCT的关键因素，目前小分子含硼药物存在硼含量低、靶向性差的问题，而纳米含硼药物存在深层肿瘤组织中的渗透性不足和在机体中不易降解的问题。本项目拟构建可生物降解的富硼载药纳米胶囊，借助热中子辐照激活实现药物在体的精准控释，并与BNCT协同治疗三阴乳腺癌。通过被动靶向，提高纳米胶囊在肿瘤中的硼摄取量；通过锆-89对纳米胶囊进行标记实现PET-CT成像，对含硼药物在肿瘤和正常组织的分布进行实时、动态监测，为热中子激活的联合治疗提供最佳的治疗窗口；纳米胶囊包载化疗药物，借助小分子的强渗透性弥补纳米硼药在肿瘤深层渗透不足的问题。利用热中子作为BNCT的“激活剂”和药物控释的“开关”，实现富硼药物的靶向递送、化疗药物的定点控释及BNCT和化疗的协同治疗。

Boron Neutron Capture Therapy (BNCT) is a binary radiotherapeutic modality and has unique advantages in the treatment of malignancies at cellular levels. Boron-containing drugs are the key factors for the realization of BNCT. At present, there are still some problems existing in the boron-containing drugs, such as low boron content and poor targeting of the small molecular boron-containing drugs, insufficient permeability and poor biodegradability of boron-containing nano-drugs in deep tumor tissues. This project aims to construct a boron-rich, drug-loaded nanocapsule, and implement it with a targeting strategy by regulating the particle size and surface modification of the nanocapsule to improve the targeting performance. The radionuclide-labeled boron-rich nanocapsules can realize PET-CT imaging which guides the implementation of BNCT by dynamic monitoring of the drug distribution in tumors and normal tissues. Chemotherapeutic small molecular drugs have strong deep tumor penetration. Thus, the chemotherapeutic drug-containing nanocapsule could solve the problem of its insufficient tissue penetration. Neutron is a "switch" for BNCT and a "switch" for precise drug release, enabling the combination of BNCT and chemotherapy. This project will provide a new strategy for the precise treatment of malignant tumors by targeted delivery of boron-rich drugs, intelligently controlled release of chemotherapeutic drugs, and the combination of multiple mechanisms.