基于GRADE的公共卫生决策证据质量分级理论及方法研究

“循证决策”“循证治理”在全球不断掀起决策科学性和有效性变革的新思潮，其精髓在于科学的证据质量分级。研究发现，当前的证据质量分级系统不能充分体现公共卫生研究的特点，从而影响证据的转化应用和卫生决策的科学性和有效性。本课题基于GRADE理念，针对公共卫生研究证据质量分级理论及方法进行研究，主要包括：1）分析公共卫生研究证据质量现状，探索公共卫生研究证据质量分级的理论框架；2）采用WHO推荐的标准化共性理论研究方法（德尔菲法、专家共识会议），进行公共卫生研究证据质量分级理论及方法研究，构建公共卫生研究证据质量分级系统；3）实证研究，应用新的证据质量分级系统，评价公共卫生研究证据质量，在实证研究中进一步完善和验证公共卫生证据质量分级系统的科学性和适用性。研究成果对促进公共卫生领域高质量证据的生产和转化、提升卫生决策水平具有重要意义和价值。

Evidence-based Policy-making and Evidence-based Governance are increasingly triggering a new trend of reform in the effectiveness and scientificalness of the policy around the world, which regard scientific evidence quality grading as the essence. Previous studies have found that the current evidence quality grading system cannot reflect the characteristics of public health research fully, which affects the translation and application of evidence, and the effectiveness and scientificalness of health policy-making. Basing on the GRADE philosophy, this proposal focuses on the theory and methods research of the research evidence quality grading of public health. The proposal will include: 1) analyzing the status of evidence quality and exploring a theoretical framework of the research evidence quality grading of public health; 2) adopting the standardized universal theoretical research methods recommended by WHO (Delphi Method, Consensus Conference Method) to conduct the theory and method research of evidence quality grading of public health, and constructing a new grading system; 3) performing empirical research, which is to apply the new evidence quality grading system to evaluate the evidence quality of public health, and to further improve and verify its scientificity and applicability. The research results will be of great significance and value to promote the production and transformation of high-quality evidence in the field of public health and improve the level of health policy-making.