碳二亚胺分子的活化及合成应用

探索、设计和合成一些新反应体系中的活性物种或活性中间体，并建立这些活性物种或活性中间体作为基本合成子，在金属催化剂或试剂的作用下，发现合成化学新反应、新方法，不仅可以从源头上革新，而且对高效发现有机合成化学新反应具有至关重要的作用和意义。本项目主要研究内容包括四个方面：(1) 基于单酰氯活化碳二亚胺的活性物种N-酰基-氯代脒与炔基硫锂反应，可构筑5-酰基-2-亚氨基噻唑啉新反应，深入、系统研究单酰氯，磷酰氯，卤代烃活化碳二亚胺的加合物与不同亲核试剂的反应；(2) 探索金属催化剂或试剂活化碳二亚胺分子，获得更加活泼的反应物种，开展它们的反应化学；(3) 基于碳二亚胺分子中C=N双键的环加成反应，合成高张力的小环化合物，并建立其在合成化学中的应用；(4) 探索双酰氯与碳二亚胺加合物的合成及应用：缺电子氮杂环卡宾的合成。

Discovery and development of novel reactions and methods based on the active intermediates in new reaction systhem are of general interest in both organometallic chemistry and synthetic organic chemistry, which not only play an important role in the innovation of original materials, but can also find efficiently new synthetically useful reactions. This project will mainly focus on the following aspects: (1) Activation of carbodiimides by acid chloride, phosphorus oxychloride or halides as well as the application of their active species in synthetic organic chemistry; (2) Activation and application of carbodiimides by metallic catalysts or reagents; (3) Synthsis and application of highly strained three- or four-membered N-containing heterocycles via cycloaddition of C=N bonds of carbodiimides; (4) Synthsis and application of N-heterocyclic carbenes having di-carbonyl electron-withdrawing groups. Our aim is to develop synthetically useful methods leading to selective synthesis of N-containing compounds via MCR strategy, and to investigate mechanism and structure-reactivity relation.