睡眠障碍是涉及全人类的重要医疗卫生公共问题，中医针灸疗法虽对睡眠障碍有疗效，但其治疗机制尚不明确，缺乏有效的信息化评判手段。本项目针对针灸治疗失眠机制研究在精准穴位刺激和深脑核团信号检测方面的重大需求，围绕如何进行精准穴位电刺激、如何长时间检测活动动物深脑核团电信号和谷氨酸浓度等关键科学问题，开展穴位刺激与深脑核团信号检测技术研究，重点突破穴位信息检测与电刺激针灸针修饰、柔性深脑核团信号检测微电极阵列制备与修饰、穴位刺激与深脑核团信号检测无线佩戴式系统集成等关键技术，研制穴位刺激与深脑核团信号检测无线佩戴式系统，并对失眠动物模型进行应用验证，获取丘脑PVT核团对印堂和百会精准穴位电刺激响应的新数据，探索穴位电刺激治疗失眠的新方法，为中医针灸和穴位信息化提供新工具，为针灸治疗失眠机制的脑科学研究提供新的手段和技术平台。

Sleep disorder is an important public health problem involving all human beings. Although traditional Chinese medicine acupuncture therapy has curative effect on sleep disorders, its therapeutic mechanism is still unclear and lacks effective information evaluation methods. This project is aimed at the needs of acupuncture treatment of insomnia mechanism, focusing on how to perform precise acupoint electrical stimulation, how to detect the deep brain nucleus electrical signal and glutamate concentration of active animals for a long time, and carries out research on acupoint stimulation and deep brain nucleus signal detection technology. The project focuses on solving key technologies such as acupoint information detection and electrical stimulation acupuncture needle modification, flexible deep brain nucleus signal detection microelectrode array fabrication and modification, system integration, and develops acupuncture stimulation and deep brain nucleus signal detection wireless wearable system. It is planned to use the insomnia animal model to verify the system to obtain new data of thalamic PVT nucleus response to Yintang and Baihui precision acupoint electrical stimulation, and to explore a new method of acupoint electrical stimulation for insomnia. This project will provide new tools for acupuncture and acupoint informationization of Chinese medicine, and provide a new means and technology platform for acupuncture treatment of insomnia mechanism brain science research.