过渡金属催化的串联反应是构建碳-碳键，碳-杂键的重要手段。本项研究的重点是利用不同官能化的乙炔基环丙烷衍生物，在过渡金属催化下形成活性金属有机中间体并进行后续的串联反应合成一系列含氮及含氧的环状化合物。.（1）通过Pd(II)催化不同官能化的乙炔基环丙烷衍生物生成烯基钯中间体，并串联与烯丙基氯，二芳基碘盐的偶联反应合成多取代杂环化合物。.（2）通过过渡金属催化官能化的乙炔基环丙烷衍生物生成烯基金属中间体，利用氟试剂或三氟甲基试剂的氧化消除合成多种含氟及三氟甲基的杂环化合物。.（3）通过过渡金属催化官能化的乙炔基环丙烷衍生物形成环丙甲基正离子中间体，并串联开环重排，环化等反应合成多取代杂环化合物。

Transition-metal catalyzed tandem reaction are an important strategies in heterocyclic synthesis by multiple bond forming . In this project, We use different functionalized ethynyl-cyclopropane derivatives to synthesize nitrogen and oxygen-containing heterocyclic compounds via transition metal-catalyzed cascade reactions: (1) Study the tandem reaction of palladium catalyzed different functionalized ethynyl cyclopropane derivatives to generate alkenyl palladium intermediate, which reacted with allyl chloride and diaryliodonium salts to synthesize polysubstituted heterocyclic compounds; (2) The transition metal-catalyzed oxidative fluorination and trifluoromethylation of different functionalized ethynyl cyclopropane derivatives to synthesize a variety of fluorinated and trifluoromethyl heterocyclic compounds; (3) Study the tandem reaction of transition metal-catalyzed different functionalized ethynyl cyclopropane derivatives to generate cyclopropylmethyl cationic intermediate, which undergo the subsequent rearrangement, cyclization reactions to synthesize polysubstituted heterocyclic compounds.