重度脊柱畸形必须借助脊柱截骨方能完成良好矫形，且常需全椎体截骨（VCR），而对截骨间隙进行过度的撑开或短缩都将引起脊髓损伤导致瘫痪。我们前期研究发现脊髓可耐受的撑开范围明显小于短缩范围，提出截骨后宜行脊柱短缩，并发现脊柱安全短缩距离与椎体高度存在明显相关性。前期研究还发现脊柱短缩时脊髓也将短缩堆积产生皱折，且其安全短缩幅度与后方椎板的切除减压范围密切相关。然而，最有效的椎板减压位置在何处？最小的切除范围是多少？不同程度的脊柱短缩与椎板减压范围是否存在对应的安全量化关系？项目拟通过山羊的动物实验，探讨脊髓皱折角度与脊髓短缩极限值之间的关系，获得椎板切除减压能够减轻脊髓皱折成角并提高脊髓安全性的可靠证据；建立脊柱短缩程度和椎板减压范围的安全关系量表，明确椎板的最佳切除位置和范围；进而量化重度脊柱畸形截骨矫形时的脊柱安全短缩范围及椎板减压范围，为重度脊柱畸形安全矫形提供一项重要的量化指导标准。

Correction of severe spinal deformities often requires osteotomy technology, and vertebral column resection (VCR) is the only effective technique to manage severe rigid spinal deformities. Howerver, spinal cord injury may occur in cases of excessive spinal shortening or distracting. Our previous studies have found that spinal cord shortening is safer than spinal cord distraction, and suggested that shortening of spinal cord is appropriate after osteotomy. The safe limit of shortening distance was strongly correlated with the vertebral body height. We also found the spinal cord was buckling as the spinal column was shortened gradually, and the safe limit of shortening distance may be largely related to the laminectomy resection length. However, where is the most effective decompression? What is the range of minimum effective laminectomy resection length? And, whether the different degrees of spinal shortening distance and laminectomy resection length have corresponding security quantitative relationship? This study aimed to investigate the relationship between spinal cord buckling angle and the safe limit of shortening distance, establish the safety relationship scale of the degree of spinal shortening distance and the laminectomy resection length, make clear the best location of laminectomy resection, gain reliable evidence that the lamina resection decompression can relieve buckling angle and improve the safety of spinal cord in a goat model. Futher more, we aimed to find out the quantitative relationship between the different degrees of spinal shortening and the laminectomy resection length to provide an important quantitative guidance standard for the safety correction of severe spinal deformity.