药物及个人护理品（PPCPs）次生污染物引起的供水二次污染导致的水质安全问题是饮用水研究领域的热点之一，也是饮用水水质面临的长期挑战。然而对于次生污染物的类型、毒性、引发的水质健康风险, 我们仍缺乏系统性的研究评价。本申请旨在利用成组短期毒理学试验和化学分析相结合的联合检测方法，对典型PPCPs中TCS在净水工艺中光解、消毒及代谢次生污染物进行综合检测，系统研究TCS次生污染物存在类型以及迁移转化规律，对次生污染物进行鉴定和毒性评价，建立相应的风险分析和评估模型，探讨次生污染物毒理学作用机制，阐明2,7/2,8-DCDD等次生污染物的产生条件和机制，在此基础上，系统评价现有净水工艺对TCS的去除效果和次生污染物的生成风险，针对性地提出基于水质安全的TCS及次生污染物生成过程控制和去除控制条件下的毒性削减技术方案，为供水部门应对PPCPs导致的供水二次污染问题的管理和控制提供科学技术支持。

Water quality and safety issues caused by uncertain and complex secondary pollutants arose by personal care products (PPCPs) became one of the research hotspots for drinking water, but also a long-term challenges for drinking water quality control. However, the secondary pollutants' species, toxicity and their potential health risk impact on water quality are still unclarity and lack of systematic researches. In this application, combined detection methods consisting of a battery of short-term genotoxicity test systems and chemical analysis are applied,secondary pollutants（photodecomposition，disinfection，and metabolism） of typical PPCPs(TCS) in the water purification process are explored comprehensively,species, migration and transformation rules of TCS secondary pollutants are studied systematically,generated secondary pollutants are identified and toxicity evaluated,corresponding risk analysis and assessment model are established, toxicology mechanism of secondary polltion are discussed,and generation conditions and mechanism of secondary pollution,for such as 2,7/ 2,8-DCDD secondary pollutants are definited, based on which, removal effect and formation risk of such substances by different control technology are evaluated, and targeted toxicity reduction control technologies under TCS secondary pollutants formation process control and elimination condition which based on water quality safety are put forward. The study will provide scientific foundation and technical direction for the water sector to deal with secondary pollution arose by PPCPs in drinking water.