饮用水中药物及个人护理品（PPCPs）等痕量污染物的检出浓度越来越高，其在消毒过程中生成的副产物往往会进一步引起水质毒性效应的增强，增加水质安全健康风险。此类副产物多属于标准中尚未有明确限值要求的新型非受控消毒副产物，其鉴定识别及生成规律和影响因素均有待于进一步研究。本申请拟构建基于样品组分分级分离的毒性测试与化学分析相结合的鉴定识别方法，在此基础上以典型酚类PPCPs为研究对象，鉴定识别氯化过程中毒性效应增强的消毒副产物，揭示消毒副产物结构与毒性效应相关性，探讨毒性效应机制，进而探明毒性效应增强的消毒副产物生成规律及其毒性效应的主要控制因子，揭示典型酚类PPCPs毒性效应增强的消毒副产物生成机制，为有效实现对毒性效应增强的消毒副产物控制提供科学依据。

Pharmaceuticals and personal care products (PPCPs) occurred frequently in drinking water, and byproducts generated by PPCPs probably enhance the toxic effects of water quality and thus pose uncertain threat to water safety and human health. Most of those byproducts belong to new unregulated disinfection byproducts, and the identification, generation mechanism and influence factors of those byproducts need further investigation. This proposal commits to develop a separation and identification method based on the physicochemical fractionation and the combination of toxicity test with chemical analysis technique; The toxic effect enhanced DBPs derived from typical phenolic PPCPs will be identified; the correlation between disinfection byproducts molecular structure and the toxic effects will be definited; and the mechanism of toxic effects would also be studied; Moreover,the forming rules of the toxic effect enhanced DBPs and the main controlling factors for the enhanced toxic effect will be investigated, and the generation mechanism of the toxic effect enhanced DBPs will be revealed. This study will provide the theoretical basis for the toxic effect enhanced DBPs control and water quality management in drinking water industry.