乳制品中抗生素残留一直是食品安全与质量控制领域迫切需要解决的问题。基于环境友好型纳米增敏材料，以微纳米技术建立背景信号低、准确率高的特异性识别抗生素的光电化学适配体传感技术集群，对保护食品安全、促进食品样品检测技术的发展具有重要意义。本项目基于申请人在食品安全监测与控制、纳米材料制备及核酸适配体快速传感检测技术开发等方面深入的前期工作积累，以非共价键结合的方式在铁金属有机框架（Iron metal-organic framework，FeMOF）表面固载无标记核酸适配体作为识别元件，以AuNPs/N-GQDs@g-C3N4纳米复合物修饰的ITO电极作为高性能光电检测元件，构建特异性识别抗生素的传感检测模型，揭示核酸适配体、纳米复合物集成体系的传感机理与信号放大机制，为发展微纳米尺度上集成和优化的抗生素检测体系，建立性能稳定、重现性好的检测器阵列提供理论基础。

Antibiotic residues in dairy products have always been an urgent problem in food safety and quality control area. To establish photoelectrochemical aptamer-based sensing technologies with low background signal and high accuracy to specifically identify antibiotics by micro-nano technology has an important significance to the protection of food safety and promoting the development of food sample detection technology, based on environment friendly nano-sensitizing materials. Based on the applicant's in-depth preliminary work in food safety monitoring and control, nanomaterial preparation and development of aptamer-based rapid detection technology, this project is to construct a sensing detection model of antibiotics and further to reveal the sensing mechanism and signal amplification mechanism of the aptamer and nanocomposite integrated systems. Of which the iron metal organic framework (FeMOF) labeled with aptamer via non-covalent bonding acts as the identification element, and ITO electrodes modified with AuNPs/N-GQDs@g-C3N4 nanohybrids acts as high-performance photoelectrochemical detection element. This work will provide a theoretical basis for the development of an antibiotic detection system integrated and optimized on the micro-nano scale and the establishment of a detector array with stable performance and good reproducibility.