本项目从配位两亲分子与金属离子出发，以二者形成的配位组装为研究对象，集中研究三类具有发光功能的配位两亲分子与金属离子的自组装结构、性质及其功能调控。同时，我们也将通过考察同一配位两亲分子与不同金属离子形成的配位组装结构的差异，结合理论模拟计算，研究配位化学带来的构象变化对自组结构及其发光性质的影响。受蛋白质别构效应启发，把生物体系中的别构效应引入自组装体系，提出“别构组装”的科学思想；受分子自组装中电位对囊泡大小的影响启发，从细胞表面电位变化的的角度理解癌细胞分裂，探索癌细胞生长的科学本质。本项目希望通过以上工作，深入理解配位化学调控分子组装的原理及规律，启迪生命科学及材料科学领域的相关研究。

This project aims at studing the self-assembling behavior of coordinating amphiphilphiles in the presence of metal ions. The structrual and functional control will be systematically investigated on the basis of three kinds of luminescent coordinating amphiphiles. Theoretical calculations will be adopted to gain the conformational change of the coordinating amphiphiles upon coordination with metal ions andt its impact on the self-assembled structures and their luminescence performance. The idea of self-assembly allostery is developed in this project, which is inspired by the protein allostery in biological system. Meanwhile, clues of the division of cancer celles is expected to be obtained from the effect of electrical potential on the size and dividing of vesicles. This proposal may help to understand the rationale of coordination chemistry in control over molecular self-assembly, and to inspire impartance researches in relating biological and material science.