JAK/STAT/SOCS信号作为调控树突状细胞（DC）活化及功能的有效途径已为众人公认，而且以DC为靶点已成为治疗包括溃疡性结肠炎(UC)等在内的自身免疫性疾病的重要策略之一。尽管临床研究表明姜黄素治疗UC安全有效，但其能否调节DC功能以治疗UC的作用机制及途径不明。本课题拟通过复制UC大鼠模型，姜黄素干预后，采用病理性损伤评分评价姜黄素治疗大鼠UC疗效，同时分离外周血及结肠系膜淋巴结中的DC，并采用Western blot 分析等方法，从DC的亚群、表型、功能、表面共刺激分子表达，外周血Th17/Treg水平和刺激淋巴细胞增殖等多个角度，全面地考察姜黄素对UC大鼠DC功能紊乱的调控作用。同时从涉及DC分化、成熟、活化的JAK/STAT/SOCS信号出发，分析JAK/STAT/SOCS信号上关键性蛋白在DC的表达水平，探索姜黄素调控UC大鼠DC功能的可能作用机制及作用靶点。

It is an effective and reliable pathway to regulate activation and function of dendritic cell (DC) by JAK/STAT/SOCS signal, and an important treated tactics of autoimmune disease including ulcerative colitis (UC) treated by DC. However, clinical studies had shown Curcumin effectively and securely treated UC, but its mechanism is not sufficiently clear to regulate DC. The study will evaluate therapeutic effect of Curcumin by score of pathological injuries after Curcumin was administrated rats with UC. From these respects as subgroup, phenotype, function, costimulatory molecules, and so on, while Curcumin will be investigated to regulate functional disorder of DC separated from peripheral blood and mesocolic lymph nodes of UC rats by flow cytometry, Western blot analyze, ELISA and immunohistochemistry. Furthermore, the critical proteins expressed on DC in JAK/STAT/SOCS signal pathway were analyzed to explore target point and mechanism of Curcumin which could regulate function of DC from UC rats on JAK/STAT/SOCS signal pathway correlated with differentiation, maturation and activation of DC.