由于纳米药物载体通常具有良好的生物相容性，其潜在环境和健康风险一直被人们忽视。实际环境中是多种污染物同时存在的，纳米药物载体对环境中有机污染物的吸附可能影响污染物的归趋、界面行为等环境地球化学过程和毒性效应，是纳米材料风险评价的重要组成部分。本项目以mPEG-PLA纳米胶束为例，利用石英晶体微天平（QCM-D）、实时无标记细胞功能分析仪（RTCA）等现代分析手段，定量研究mPEG-PLA纳米胶束对有机质和DDT的吸附作用， mPEG-PLA纳米胶束与DDT及其复合物的水-生物膜界面行为，以及纳米胶束复合物对模型细胞的毒性效应及机制，建立相关的测试和研究方法，为准确评价纳米药物载体和有机污染物的相互作用、界面行为及其复合生物生态风险提供技术手段和数据支持，从而促进纳米材料风险管控体系的平台建设。

Due to the biocompatibility of nanocarriers, inadequate attention has been paid to their potential risks towards the environment and human health until now. However, since a variety of pollutants are coexisting in the real environment, the adsorption of organic pollutants on the nanocarriers may potentially impact their environmental geochemical behaviors, including the fate and interface behavior, as well as the toxic effects, which is an important aspect of the risk assessment of nanomaterials. In the project, we take mPEG-PLA nanocarriers as an example to quantitatively investigate the adsorption interactions between DDT, dissolved organic matter (DOM), and the mPEG-PLA nanocarriers, to monitor their water-biomembrane interface behaviors, and to study the combined toxic effects against the model cells. With the applications of the advanced analyzing techniques, like quartz crystal microbalance with dissipation (QCM-D) and real-time cell analysis (RTCA), we will provide an accessible approach to predict and assess the adsorption interactions, interface behaviors, and the combined risks of nanocarriers and the organic pollutants. The results will be useful for the construction of the risk management and control system of nanotechnologies and nanomaterials.