微波热消融在肿瘤治疗中扮演着越来越重要的角色，但仍然存在疗中难以实现实时疗效评估和剂量控制的瓶颈问题，手术存在一定盲目性，不可避免影响治疗效果。本课题将微创功能近红外光谱（fNIRs）技术与微波热消融有机结合，通过全程实时采集微波热消融疗中肿瘤消融靶区组织参数和温度，探索新的疗效评估因子，建立疗效评估和剂量控制模型，满足临床疗效质量保证需求。主要研究内容：1.建立一套完整的fNIRs与微波热消融结合的术中实时组织参数测试系统；2.通过离体与荷瘤动物模型实验，探索微波肿瘤热消融疗效评估因子，建立肿瘤有效消融体积和有效治疗剂量（量-效关系）数学模型；3.通过离体与荷瘤动物微波热消融实验评估治疗效果并修正数学模型。课题创新：提出了一种热消融疗效评估新技术，将目前热消融疗效从经验性定性评估提升到精确的数字定量评估，达到降低治疗风险、提高疗效的目的，同时前期预实验结果证实了技术方案的可行性。

Microwave thermal ablation plays a more and more important role in the treatment of tumor, but there are still difficult to achieve the bottleneck problem of curative effect assessment and dosage control in real-time operation, clinical operation is still blindness, curative effect is impacted. we will combine minimal invasion functional near infrared spectroscopy ( fNIRs ) technology with the microwave ablation together, through real-time acquisition of tissue parameters and temperature of microwave ablation target to explore the efficacy assessment factors and establish curative effect and dose control model, to meet the demand of clinical quality assurance. The main research contents: 1 the establishment of a complete set of fNIRs and microwave thermal ablation combined with intraoperative real-time parameter test and evaluation system; 2 microwave thermal ablation of tumors and Its mechanism study on evaluation of curative effect by in vitro and in vivo experiments, including the establishment of effective inactivation volume model and effective treatment dose model;3 by in vitro and in vivo tumor ablation experimental to assess curative effect, and correct evaluation mathematics model. The innovation of this study is that a new technology for thermal ablation efficacy assessment is proposal, and empirical qualitative assessments of thermal ablation is improved to digital precise quantitative assessment, to reduce risk, improve the curative effect, which has important value in clinical application，Also our preliminary experimental results confirm the feasibility of technical solutions.