近年有关药物及其转化产物的环境污染问题受到人们的广泛关注。其中大环内酯类是由链霉菌产生的一类具有14~16元环内酯结构的抗生素，使用量大，在城镇污水处理厂甚至饮用水厂广泛检出。氯化消毒处理工艺普遍应用于（污）水处理厂，残留的大环内酯类抗生素会在氯化消毒处理中发生转化反应，但转化机制及其消毒副产物仍旧不是很清楚。本项目以6种常用大环内酯类抗生素为研究对象，实验室模拟研究大环内酯类抗生素在氯化消毒过程中的去除特性，构建其与有效氯的形态反应动力学模型；利用高分辨质谱技术分析鉴定氯化处理过程中大环内酯类抗生素的消毒副产物，结合理论化学计算方法推演反应途径与转化机制；通过成组微生物毒性测试方法，评估消毒过程中毒性变化规律。进一步考察光氯联用对大环内酯类抗生素的去除效率，探讨生成的活性反应物种与大环内酯类抗生素的反应机理。研究成果为有效控制环境中大环内酯类抗生素及其氯化消毒副产物提供科学依据。

In recent years pharmaceuticals and their transformation products have received increasing attentions in general public and scientific community due to their environmental contamination issue. The macrolides, produced mostly by Streptomyces and related species, are a class of antibiotics possessing a 14-16 lactone ring to which sugars are attached. The macrolides have been widely detected in Wastewater Treatment Plants and Drinking Water Treatment Plants. Considering the prevalence of chlorination in drinking water and wastewater treatment process, it is very necessary to study the chlorination products of macrolides and their removal mechanism. This project aims to investigate the potential for removal of selected macrolides (clarithromycin, erythromycin, roxithromycin, oleandomycin, leucomycin and tylosin) during chlorination process by species-specific reaction kinetics, propose the chlorination reaction pathways of selected macrolides based on products identification and theoretical calculation, evaluate the safety of above chlorination process by using microbial assay for toxicity risk assessment. We will also study the effect of simulated UV and solar light on the chlorination of macrolides by analysis of reactive species, such as HO•, Cl•、ClO•, and O3. This project will provide the scientific basis for mitigation of macrolides and their chlorination products in aquatic environments.