促进内源性神经元再生是防治阿尔茨海默病的新策略、新途径。初级纤毛“体小而强大”是突出于细胞膜的极小细胞器。初级纤毛Shh信号转导异常能诱导与加重神经元再生障碍是AD病理机制新热点。本课题拟在前期研究基础上，初步以SAMP8小鼠为研究载体，以神经分化池海马齿状回为研究重点部位，采用相关分子生物学技术，首次以初级纤毛介导Shh信号通路为切入点，探讨神经元初级纤毛的形态功能变化与AD神经元损伤的关系；从初级纤毛相关受体与Shh信号蛋白间相互作用，探讨初级纤毛Shh信号转导在AD神经元再生障碍过程中的调控机制；进而深入揭示针灸深靶点、多节点、长时效地促进神经再生，保护神经元功能以防治AD的效应机制，为针灸防治AD的效应机制提供新的线索与实验依据。

Promoting the regeneration of endogenous neurons is a new strategy and a new way to prevent and treat Alzheimer's disease. Primary cilia "small body strong power", is a tiny organelle that protrudes from the cell membrane. Primary ciliary Shh signal transduction is a new hot spot of AD pathology, which can can induce and aggravate neuronal dysplasia. Based on the previous research work, APP / PS1 mice were used as the target, and the hippocampal dentate gyrus of the neuron shunt as the focal point. The related molecular biology technique was used. For the first time, the primary cilia-mediated Shh signaling pathway as a starting point, to investigate the relationship between the morphological changes of neuronal primary cilia and the damage of AD neurons; to discuss the mechanism of coordination with Shh signaling protein on the regeneration of AD neurons. It provides a new clue and experimental basis for the further investigation of the effect of acupuncture and moxibustion intervention on the target, multi-link, long-term promotion of nerve regeneration, protection of neuronal function and prevention and treatment of AD.