基于多巴胺及其衍生物的新型磁性纳米固相萃取剂的制备及其在环境分析中的应用

按照原青年基金项目的目标，成功制备了C18和氨丙基混合官能团修饰的磁性纳米吸附剂，海藻酸聚合物或磷脂双分子包覆的及表面性质可调控的碳材料包覆的磁性纳米吸附剂。该类吸附剂既具有纳米材料的高比表面积和强吸附性能，又对特定类型有机污染物具有选择性富集能力，还表现出优良的抗环境介质干扰能力。该研究为复杂基体环境样品中有机污染物高效、快速富集提供了一种新思路，课题研究结果已在Anal Chem，J Chromatogr A和Anal Chim Acta等期刊上发表论文7篇，并获两项授权专利。本研究项目将继续新型纳米材料的制备及在环境样品前处理中的应用研究，拟以多巴胺及其衍生物和纳米Fe3O4为基质，利用多巴胺的自聚合、粘附、氧化还原和易于修饰的特性，高效、绿色、方便、可控地制备官能团种类丰富的通用型或选择型的新型磁性纳米固相萃取剂。本项目是将纳米材料、仿生修饰和磁性固相萃取等结合为一体的创新性研究。

According to the original plans of the Young Scientist Fund (No. 20907061), different kind of magnetic nanomaterials adsorbents were synthesized successfully including those modified with octadecyl (C18) and aminopropyl mixed groups, coated with alginate biopolymers or phosphatidylcholine bilayer and encapsulated with surface-tunable carbon. These adsorbents not only possessed large specific surface areas and strong adsorption trends to pollutants, but also could selectively preconcentrate certain kind of organic pollutants and showed excellent anti-interference ability to environmental matrixes. This project has provided a novel concept to efficiently and quickly enrich organic pollutants from environmental samples with complex matrixes. Several research papers about this research have been published in famous journals including Anal Chem, J Chromatogr A, and Anal Chim Acta and two patents have been authorized. The new project continuously focuses on the preparation of novel nanomaterials and their application in sample pretreatment. We propose a new efficient, “green”, convenient, and controllable technique to synthesize solid-phase extraction (SPE) adsorbents based on dopamine or its derivatives and nanoscaled Fe3O4 taking advantage of the special properties of dopamine such as auto-polymerization, adhesion, redox, and easy to modify. The SPE adsorbents with various functional groups of general type or selected type can be prepared with this new technique. The new project is an original scientific research work combined nanomaterials, biomimetic modification and magnetic SPE techniques.