项目旨在合成多种可同时作为固相萃取吸附剂和MALDI基质的复合磁性纳米材料，探讨其在环境或生物样品中快速萃取富集有机污染物并直接用基质辅助激光解析电离飞行时间质谱（MALDI-TOF-MS）检测中的应用。采用共沉淀、热分解、溶胶-凝胶等方法制备出表面积大、粒径均一、分散性和生物相容性好的具有核/壳式或包埋式结构的聚合物或亲水性碳包覆的、负载纳米金/银/铂的和磁性碳纳米管、石墨烯或富勒烯等复合磁性纳米材料吸附剂。考察吸附剂对有机污染物的萃取能力和辅助激光诱导解析和离子化的性能，建立环境或生物样品中有机污染物的高效萃取富集方法，与MALDI-TOF-MS检测技术联用，实现对复杂基体样品中微量污染物的高效、灵敏、快速分析。项目创造性地将纳米材料、磁性分离、固相萃取技术和MALDI-TOF-MS分析检测技术结合为一体，简化了样品前处理方法，减少了目标物的损耗，缩短了目标污染物分析检测的分析时间。

This project focuses on the synthesis of various kinds of magnetic nanocomposites, which can serve both as solid-phase extraction adsorbents (SPE) and MALDI matrix, and their application in extracting organic contaminants from environmental or biological samples rapidly and measuring directly using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS). Core/shell structured or embedded polymers or hydrophilic carbon with low degree of graphitization coated magnetic nanocomposites, gold/silver/platinum nanoparticles loaded magnetic nanomaterials and magnetic carbon nanotubes, graphene, or fullerene composites are synthesized through coprecipitation, thermal decomposition, and sol-gel methods. These magnetic nanocomposites have large surface areas, uniform particle size and good dispersion and biocompatibility. The extraction performance of the prepared magnetic nanocomposites to organic contaminants and enhanced desorption/ionization efficiency of targets under the action of laser pulses on these nanocomposites are investigated and an efficient magnetic SPE method will be established to achieve the efficient, sensitive and rapid analysis of trace contaminants in environmental or biological samples in conjunction with MALDI-TOF-MS detection technology. In this project, novel sample pretreatment and detection method is established through creative combination of nanomaterials, magnetic separation, SPE technology and MALDI-TOF-MS detection technique, which simplifies the sample pretreatment method, decreases targets loss and shortens the analytical time.