异色满结构单元是一类非常重要的药效团，广泛存在于很多活性天然产物和药物分子中。鉴于现有制备方法的不足，我们拟通过本项目开展基于Catellani反应机理的异色满结构合成新策略研究，选取廉价易得的环氧化合物和芳基碘作为合成异色满的主要原料。通过将环氧化物作为新型烷基化试剂与芳基碘以及终止试剂发生Catellani类型的反应，发展出汇聚式合成异色满结构单元的新策略，并在此基础上完成复杂天然产物berkelic acid和chaetophenol D的高效全合成。

The isochroman motif is an important pharmacophore that exists in many bioactive natural products and therapeutic agents. Due to the disadvantages of state-of-the-art strategies for isochroman synthesis, we plan to develop a novel protocol based on the Catellani reaction logic, by selecting readily available epoxides and aryl iodides as the main starting materials. To this end, epoxides will be utilized as the alkylating reagents to react with the aryl iodides and suitable terminating reagents in a Catellani-type reaction, providing isochroman in an efficient and convergent manner. Total synthesis of complex natural products berkelic acid and chaetophenol D will be investigated with the aforementioned stragety as the key step.